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PW01-15 - Neurocognitive Function in Clinically Stable Patients With Bipolar Disorder or Schizophrenia and Normal Controls

Published online by Cambridge University Press:  17 April 2020

G. Konstantakopoulos ,
P. Patrikelis ,
N. Ioannidi ,
A. Soumani ,
P. Oulis ,
D. Sakkas ,
D. Ploumpidis  and
G. Papadimitriou
G. Konstantakopoulos
Affiliation:
Department of Psychiatry, Eginition Hospital, University of Athens, Medical School, Athens, Greece Section of Cognitive Neuropsychiatry, Department of Psychiatry, Institute of Psychiatry, King's College London, London, UK
P. Patrikelis
Affiliation:
Department of Psychiatry, Eginition Hospital, University of Athens, Medical School, Athens, Greece
N. Ioannidi
Affiliation:
Department of Psychology, University of Athens, Greece
A. Soumani
Affiliation:
Department of Psychiatry, Eginition Hospital, University of Athens, Medical School, Athens, Greece
P. Oulis
Affiliation:
Department of Psychiatry, Eginition Hospital, University of Athens, Medical School, Athens, Greece
D. Sakkas
Affiliation:
Department of Psychiatry, General Hospital ‘G. Gennimatas’, Athens, Greece
D. Ploumpidis
Affiliation:
Department of Psychiatry, Eginition Hospital, University of Athens, Medical School, Athens, Greece
G. Papadimitriou
Affiliation:
Department of Psychiatry, Eginition Hospital, University of Athens, Medical School, Athens, Greece

Abstract

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Objectives

There is a substantial body of evidence that cognitive deficits in schizophrenia and bipolar disorder persist after the subsidence of active symptoms. The aim of the study was to assess and compare the cognitive functioning of patients with clinically stable schizophrenia and bipolar disorder.

Methods

Attention, memory, verbal learning ability, visuospatial ability, executive functions and social cognition were assessed in 21 patients with schizophrenia in remission, 23 euthymic bipolar-I patients, and 27 normal controls, using WAIS - Vocabulary, Block design, and Digit span, Stroop Test, Babcock Story Recall Test, Rey Auditory Verbal Learning Test (RAVLT), Trail Making Test (Trails A and B), Wisconsin Card Sorting Test (WCST), and Faux Pas Recognition Test. The three groups were matched for gender, age and education. One-way ANOVA with post hoc Bonferroni corrections was used for the between groups comparisons.

Results

Both bipolar disorder and schizophrenia patients were significantly impaired on tests of working memory, learning abilities, and executive functions compared to control subjects. Patients with schizophrenia performed significantly worse than patients with bipolar disorder on attention and verbal memory tasks, whereas the latter performed worse than normal controls on visuospatial ability tasks.

Table 1

Comparison of neuropsychological function

 Bipolar Disorder Mean (SD)Schizophrenia Mean (SD)Normal controls Mean (SD)FpPost-hoc test (p)
WAIS - Vocabulary10.1 (1.8)10.2 (1.8)12.0 (1.6)6.06.004S < N (.015) B < N (.008)
WAIS - Block design7.9 (2.5)9.9 (3.6)10.3 (2.7)3.76.032B < N (.039)
Stroop - Word84.3 (18.7)82.3 (26.8)97.7 (16.5)4.03.022S < N (.038)
Stroop - Colour59.5 (12.3)56.8 (16.8)72.0 (12.1)8.74.000S < N (.001) B < N (.006)
Babcock - Delay recall12.1 (3.9)7.7 (3.3)13.2 (3.3)15.71.000S < N (.000) S < B (.000)
WCST - categories2.4 (1.4)2.5 (1.3)3.1 (1.1)2.49.090ns
WCST - perseverative errors14.6 (13.1)18.5 (16.4)11.1 (8.2)1.30.280ns
Trails B164.1 (83.2)170.2 (76.8)86.7 (43.3)11.68.000S > N (.000) B > N (.001)
Faux Pas - detection38.6 (11.6)40.1 (14.6)46.2 (9.6)2.64.080ns

Conclusions

Our results indicate that stable schizophrenia and euthymic bipolar disorder exhibit different but overlapping profiles of cognitive impairment.

Type
Affective disorders / Unipolar depression / Bipolar disorder
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E1417
Copyright
Copyright © European Psychiatric Association 2010
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