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Persistent emotional stress, fatigue and impaired neurocognitive function in recovered COVID-19 patients: a longitudinal prospective study

Published online by Cambridge University Press:  01 September 2022

A. Rogiers ,
S. Launay ,
G. Duque ,
E. Soukias ,
S. Van Eycken ,
T. Besse-Hammer ,
D. Sanchez-Rodriguez ,
M. Chalon ,
M.-D. Gazagne  and
E. Maillart
...Show all authors
A. Rogiers
Affiliation:
CHU Brugmann, Department Of Psychiatry, Brussels, Belgium Vrije Universiteit Brussel, Faculty Of Medicine, Brussels, Belgium
S. Launay*
Affiliation:
CHU Brugmann, Department Of Psychiatry, Brussels, Belgium
G. Duque
Affiliation:
CHU Brugmann, Department Of Psychiatry, Brussels, Belgium
E. Soukias
Affiliation:
CHU Brugmann, Department Of Psychiatry, Brussels, Belgium
S. Van Eycken
Affiliation:
CHU Brugmann, Department Of Psychiatry, Brussels, Belgium
T. Besse-Hammer
Affiliation:
CHU Brugmann, Clinical Trial Department, Brussels, Belgium
D. Sanchez-Rodriguez
Affiliation:
CHU Brugmann, Geriatry, Brussels, Belgium
M. Chalon
Affiliation:
CHU Brugmann, Physical Medicine And Rehabilitation, Brussels, Belgium
M.-D. Gazagne
Affiliation:
CHU Brugmann, Neurology, Brussels, Belgium
E. Maillart
Affiliation:
CHU Brugmann, Department Of Infectious Diseases, Brussels, Belgium
F. Benoit
Affiliation:
CHU Brugmann, Geriatry, Brussels, Belgium
M. Surquin
Affiliation:
CHU Brugmann, Geriatry, Brussels, Belgium
F. Corrazza
Affiliation:
CHU Brugmann, Immunology, Brussels, Belgium Université Libre de Bruxelles, Faculty Of Medicine, Brussels, Belgium
O. Michel
Affiliation:
CHU Brugmann, Immunology, Brussels, Belgium Université Libre de Bruxelles, Faculty Of Medicine, Brussels, Belgium
C. Kornreich
Affiliation:
CHU Brugmann, Department Of Psychiatry, Brussels, Belgium Université Libre de Bruxelles, Faculty Of Medicine, Brussels, Belgium
*
*Corresponding author.

Abstract

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Introduction

Several surveys report that post-COVID-19 patients (pts) could be at risk of persistent emotional distress, fatigue and impaired neurocognitive function (NCF).

Objectives

The aim was to assess emotional distress, fatigue and NCF in order to provide adequate care.

Methods

Patients with persistent physical or mental symptoms, at least 8 weeks post-COVID-19, were eligible for this ongoing prospective longitudinal single center trial. Data on depression, anxiety, cognition, post-traumatic stress symptoms (PTSS) and fatigue were collected using 4 validated questionnaires at study entry (T0) and at 6 months (T1).

Results

Ninety-three pts were recruited between November 2020-March 2021. Test results from 64 eligible pts (15 male pts) were analyzed at T0; 63 pts (98%) were treated in outpatient settings. Median age was 47 years [range 27-75]). Median time since COVID-19 was 29 weeks [range 8-53]. Twenty-two pts (34%) had a history of psychiatric disorders. According to the Hospital Anxiety Depression Scale (HADS), 44 pts (73%) reported anxiety symptoms and 26 pts (41%) reported depressive symptoms; 48 pts (69%) reported cognitive complaints according to the Cognitive Failure Questionnaire and 29 pts (45%) suffered from PTSS, according to the Post-Traumatic Stress Disorder Checklist-Civilian Version (PCL-C). Fifty-five pts (86%) had an elevated score on the Fatigue Severity Scale, indicating severe fatigue. Twenty-seven pts (42%) were still on sick leaf. Diminished social support and psychiatric history were predictive factors for neurocognitive dysfunction and PTSS.

Conclusions

A majority of patients who recovered physically from COVID-19, are at risk for suffering from persistent anxiety, PTSS and neurocognitive dysfunction.

Disclosure

No significant relationships.

Keywords

Covid-19cognitive functionpost-traumatic stress symptomsAnxiety
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S496
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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