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P-495 - Gender Difference in Antidepressant-related Sexual Dysfunction in Patients With Major Depressive Disorder (mdd)

Published online by Cambridge University Press:  15 April 2020

J. Isaac ,
T. Lee ,
K. Chin Chen ,
T. Lieh Yeh ,
I. Hui Lee ,
P. See Chen ,
S.-H. Lin  and
Y. Kuang Yang
J. Isaac
Affiliation:
Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal, Taiwan R.O.C
T. Lee
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, Taiwan R.O.C
K. Chin Chen
Affiliation:
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan R.O.C
T. Lieh Yeh
Affiliation:
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan R.O.C
I. Hui Lee
Affiliation:
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan R.O.C
P. See Chen
Affiliation:
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan R.O.C
S.-H. Lin
Affiliation:
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan R.O.C
Y. Kuang Yang
Affiliation:
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan R.O.C

Abstract

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Introduction:

It is known that Sexual Dysfunction (SD) is higher in patient with depression than in the general population. Though antidepressant seems to worsen the situation, there are also indications that the gender may play a role on it.

Objective:

Evaluate the gender effect of sexual function among unmedicated MDD, MDD receiving antidepressant, and healthy controls.

Methods:

The sample was formed by male and female Taiwanese outpatients in three age and sex matched groups, with sixty nine participants per group: unmedicated MDD, MDD receiving antidepressant, and healthy controls. the diagnoses of depressions were performed according DSM-IV and Taiwanese Depression Questionnaire. SD was evaluated with the Chinese version of the Changes in Sexual Functioning Questionnaire. Finally, the data was analyzed using SPSS software v17. Mixed designed ANOVA was used.

Results:

There are significant differences between males and females CSFQ results (sex main effect F = 82.44, p < 0.001) and between groups (group main effect F = 3.48, p = 0.034). Additionally, the 2-way interaction between sex and group was also significant (F = 3.40, p = 0.036). Simple main effect analysis shows differences among male participants, between healthy and medicated males (F = 11.41, p = 0.002), but not in female (F = 1.58, p = 0.21). However the statistics weren’t different between females groups, the medicated expresses better results (similar to healthy group) than the unmedicated one.

Conclusions:

SD is different between genders in each of the groups. Antidepressant seems to increase SD in man, while improves sexual satisfaction/function among depressive woman. We speculate that psychological improvement after treatment may have different impact between genders on sexual satisfaction.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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