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P-380 - Spatial Cognition in Nogo-a-deficient Transgenic Rats as an Animal Model: Effects of Ageing and Behavioral Conditions

Published online by Cambridge University Press:  15 April 2020

A. Stuchlik
Affiliation:
Institute of Physiology AS CR, Mannheim, Germany
T. Petrasek
Affiliation:
Institute of Physiology AS CR, Mannheim, Germany
Z. Kristofikova
Affiliation:
Prague Psychiatric Center, Prague, Czech Republic, Mannheim, Germany
M. Vrajova
Affiliation:
Prague Psychiatric Center, Prague, Czech Republic, Mannheim, Germany
I. Prokopova
Affiliation:
Institute of Physiology AS CR, Mannheim, Germany
S. Berger
Affiliation:
Central Institute of Mental Health, Mannheim, Germany
K. Schonig
Affiliation:
Central Institute of Mental Health, Mannheim, Germany
D. Bartsch
Affiliation:
Central Institute of Mental Health, Mannheim, Germany
K. Vales
Affiliation:
Institute of Physiology AS CR, Mannheim, Germany
D. Ripova
Affiliation:
Prague Psychiatric Center, Prague, Czech Republic, Mannheim, Germany

Abstract

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Introduction:

Research into mechanisms of interaction between growth and inhibitory proteins of the CNS and behavioral expressions of healthy and disordered brain is one of the contemporary topics. A knockdown model with decreased expression of Nogo-A protein in neurons was developed on the genetic background of Sprague-Dawley wildtypes. Disruption of this inhibitory factor was hypothesized to result in behavioral abnormalities, which were studied both in young, middle age (6 months) and aged (12 months) rats.

Methods:

Animals were tested in a battery of Carousel maze variants with various demands for segregation of spatial information and flexibility; animals avoided an unmarked sector of either stable or rotating arena; moreover the sector could be defined in room- or arena-frame. A shortened Carousel maze battery and Morris water maze (MWM) including one- trial matching-to-place and reversal configurations was used.

Results:

Nogo-A-deficient rats were impaired in the final phases of the Carousel maze battery but their spatial working memory tested in the MWM was intact. Middle-aged and aged groups were differently affected in the battery, but deficits in young animals were observed not to be worsened with ageing. Concept of multidirectional age-related alterations in this animal model is further supported by biochemical brain changes.

Conclusion:

Nogo-A-deficient rats may serve as an extremely useful model of neurodevelopmental deficit, which may manifest by behavioral changes accessible to phenotyping and in-depth analysis. Relevance of this approach for animal models of neuropsychiatric models will be discussed.

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Copyright © European Psychiatric Association 2012
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P-380 - Spatial Cognition in Nogo-a-deficient Transgenic Rats as an Animal Model: Effects of Ageing and Behavioral Conditions
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