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P-26 - Psychomotor Speed in Opioid Addicted hiv (+) and hiv (-) Subjects After Methadon Single Dose Administration

Published online by Cambridge University Press:  15 April 2020

J. Feit ,
E. Nowińska ,
K. Pasgreta ,
W. Lasoń ,
M. Ziółkowski  and
E. Gorzelańczyk
J. Feit
Affiliation:
Non-Public Health Care Center Sue Ryder Home, Warszawa, Poland
E. Nowińska
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Collegium Medicum of Nicolaus Copernicus University in Torun, Bydgoszcz, Warszawa, Poland
K. Pasgreta
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Collegium Medicum of Nicolaus Copernicus University in Torun, Bydgoszcz, Warszawa, Poland
W. Lasoń
Affiliation:
Faculty of Medicine, Jagiellonian University Medical College, Krakow, Warszawa, Poland
M. Ziółkowski
Affiliation:
Department of Psychiatry Nursing, Collegium Medicum of Nicolaus Copernicus University in Torun, Bydgoszcz, Warszawa, Poland
E. Gorzelańczyk
Affiliation:
Institute of Psychology, Polish Academy of Sciences, Warszawa, Poland

Abstract

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Introduction

Research on cognitive functions in opioids addicted subjects treated with methadone indicate that cognitive functions are in various degree disturbed.

Aims/objectives

This study aims to assess the impact of a therapeutic dose of methadone on psychomotor velocity in HIV (+) and HIV (-) subjects treated with substitution therapy.

Methods

73 patients were examined, 32 HIV (-) and 41 HIV (+) (mean age 39.5 ± 7.7) treated with methadone for an average of 54 months. The examination was conducted twice: before and about 1.5 hours after the administration of a therapeutic dose of methadone (mean dose: 83 ± (34) mg). A test sheet was placed on the graphic tablet. In both parts of the test execution time was measured.

Results

It was found that the average time of TMT A completion before methadone administration in HIV (-) individuals is 40.2 ± (12)s and in HIV (+) ones - 50.6 ± (25.7)s, after methadone administration in HIV (-) individuals: 36.4 ± (10.2)s, in HIV (+) - 42.4 ± (18,8,51)s. The value of T test in HIV (-) and HIV (+) subjects before the administration of a therapeutic dose of methadone amounts to t = 2.1083, p = 0.0385, and after the application it amounts to t = 1.6157, p = 0.1106.

Conclusion

Psychomotor velocity measured by TMT A Test before the administration of a therapeutic dose of methadone increases significantly in HIV(-) subjects in comparison to HIV (+) ones. Psychomotor velocity after the administration of a therapeutic dose of methadone is not statistically significant in HIV (-) subjects as compared to HIV (+) ones.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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