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P-162 - Depressive and Euthymic Phase of Bipolar Disorder: Cognitive Profiling by Neuropsychological Assessment

Published online by Cambridge University Press:  15 April 2020

S. Ammendola
Affiliation:
Neuroscience Section Psychiatry, University School of Medecine Federico II, Naples, Italy
M. Apuzzo
Affiliation:
Neuroscience Section Psychiatry, University School of Medecine Federico II, Naples, Italy
A. Calento
Affiliation:
Neuroscience Section Psychiatry, University School of Medecine Federico II, Naples, Italy
A. Cervone
Affiliation:
Neuroscience Section Psychiatry, University School of Medecine Federico II, Naples, Italy
F. Kusmann
Affiliation:
Neuroscience Section Psychiatry, University School of Medecine Federico II, Naples, Italy
D. Galletta
Affiliation:
Neuroscience Section Psychiatry, University School of Medecine Federico II, Naples, Italy
M. Casiello
Affiliation:
Neuroscience Section Psychiatry, University School of Medecine Federico II, Naples, Italy

Abstract

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Introduction

There is an increasing evidence that several cognitive areas as executive functioning, verbal memory and visual-spatial abilities, are impaired during the acute phase of Bipolar Disorder (BD) and persist even in the euthymic periods.

Objectives and aims

The aim of the study was to characterize cognitive profile in subjects affected by BD-I and BD-II and to compare them to healthy controls (HC), in order to analyse the possible influence of depressive or euthymic phase on neuropsychological performances.

Methods

We recruited 35 outpatients with BD (DSM-IV TR), 20 BD-I and 15 BD-II, in both euthymic or depressive phase clinically assessed. All subjects affected by any other DSM-IV TR axis I disorder were excluded. Results were compared to HC group composed by 11 subjects without neurological disorders, alcohol or drug abuse and any lifetime psychiatric treatment. Each group underwent a comprehensive neuropsychological assessment.

Results

Our results indicated that case group (BD-I/II) showed significantly lower scores at the Raven Test (p < 0.001) and executive tests (p = 0.007) compared to HC. No difference were observed between depressed and euthymic patients. Compared to healthy group euthymic and depressed patients showed significantly lower scores at Raven Test.

Conclusions

In our sample cognitive impairment is present, as indicated in literature, in each phase of Bipolar Disorder. Logical reasoning seems to be the assessment tool more influenced by the clinical phase of the pathology. The analyses of the impact of depressive/euthymic phase did not show any difference between depressed and euthymic subgroups.

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Copyright
Copyright © European Psychiatric Association 2012
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