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P-1224 - Night-time/day-time Antioxidant Status Levels in Paranoid Schizophrenic Inpatients

Published online by Cambridge University Press:  15 April 2020

E. Díaz Mesa ,
A. Morera Fumero ,
P. Abreu González ,
A. Jiménez Sosa ,
M. Henry ,
L. Fernández López  and
R. Gracia Marco
E. Díaz Mesa
Affiliation:
Service of Psychiatry, University Hospital of the Canaries, La Laguna, Spain
A. Morera Fumero
Affiliation:
School of Medicine, University of La Laguna, Santa Cruz de Tenerife, Spain
P. Abreu González
Affiliation:
Department of Physiology, University of La Laguna, Santa Cruz de Tenerife, Spain
A. Jiménez Sosa
Affiliation:
Research Unit, University Hospital of the Canaries, La Laguna, Spain
M. Henry
Affiliation:
Service of Psychiatry, University Hospital of the Canaries, La Laguna, Spain
L. Fernández López
Affiliation:
Service of Psychiatry, University Hospital of the Canaries, La Laguna, Spain
R. Gracia Marco
Affiliation:
Service of Psychiatry, University Hospital of the Canaries, La Laguna, Spain

Abstract

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Introduction

The Total Antioxidant State (TAS), expressed as equivalent to the total antioxidant capacity of blood plasma. It is the cumulative ability to trap molecules, as H2O2 and free radicals such as RO, ROO, and O2.

Objetives

Our aim is to describe the TAS levels in schizophrenic patients and to analyze if this marker has got a circadian rhythm. The only study in humans on this subject has carried out by Benot et al (1999) in healthy subjects, which has reported that there was a circadian rhythm of TAS, with a peak night at 01:00, which correlated directly with melatonin (MLT).

Methods

The sample was comprised by 43 paranoid schizophrenic inpatients.Blood samples were extracted by venipuncture at 12:00 and 24:00 hours. TAS levels were measured three times: at admission, discharge and three months after discharge. Clinical state was assessed by means of the Clinical Global Impression Scale (CGI). TAS serum levels were measured by ELISA techniques.

Results

Our results show that there is statistical significance between 12:00 and 24:00 for the TAS at admission and three months control. This means that at both times, the income and control of the three months, the levels of midday TAS is significantly higher than the midnight TAS. However, these differences did not occur at discharge.Respect to CGI there are differences in clinical status, less high-control.

TASI

0,66 ± 0,1420,60 ± 0,158,p < 0,027.

TASA

0,64 ± 0,1530,63 ± 0,1350,740.

TASC

0,84 ± 0,100,0,76 ± 0,113p < 0,001.

CGI-SI

4,37 ± 0,846,3,05 ± 0,754,3,37 ± 0,720.

CGI-GI

3,70 ± 0,640,1,77 ± 0,895,2,23 ± 1,455.

Conclusions

Our results point to the fact that serum TAS may be considered as a possible marker of psychopathological descompensation worsening.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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