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P0311 - Orexigenic and anorexigenic peptides do not differentiate two types of anorexia nervosa. The preliminary study

Published online by Cambridge University Press:  16 April 2020

M. Janas-Kozik ,
M. Stachowicz ,
A. Zajdel ,
A. Wilczok ,
K. Krysta ,
I. Krupka-Matuszczyk  and
U. Mazurek
M. Janas-Kozik
Affiliation:
Department and Clinic of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland Child and Adolescent Psychiatry and Psychotherapy Ward, John Paul II Pediatric Center, Sosnowiec, Poland
M. Stachowicz
Affiliation:
Department of Molecular Biology, Medical University of Silesia, Katowice, Poland
A. Zajdel
Affiliation:
Department of Biopharmacy, Medical University of Silesia, Katowice, Poland
A. Wilczok
Affiliation:
Department of Biopharmacy, Medical University of Silesia, Katowice, Poland
K. Krysta
Affiliation:
Department and Clinic of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland
I. Krupka-Matuszczyk
Affiliation:
Department and Clinic of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland
U. Mazurek
Affiliation:
Department of Molecular Biology, Medical University of Silesia, Katowice, Poland

Abstract

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Background and Aims:

Anorexia nervosa is a serious eating disorder with highest mortality among psychatric disorders. DSM-IV classification differentiates two type of Anorexia Nervosa (AN): the restricting type (AN-R) and the binge-eating/purging type (AN-BP). Orexigenic and anorexigenic peptides and cytokines are involved in mechanism of food intake and energy balance. Four young women suffered from Anorexia Nervosa (two with AN-BP and two with AN-R) took part in the study. Three girls were our reference group. The aim of our study was to estimate of differentiates genes between two types of Anorexia Nervosa: AN-R and AN-BP.

Methods:

The total RNA was extracted from peripheral blood mononuclears. The oligonucleotide microarray method (HG-U133A, Affymetrix) was used to determine the expression profile of 161 transcripts for genes connected with AN. The oligonucleotide microarray method analyzes genes expression by using the phenomenon of hybridization of single-thread RNA fragments with complementary DNA probes. The results were normalized using RMAExpress. The Bland Altman method was used to examine transcripts of genes which differentiate two types of AN.

Results:

Among 161 transcripts (cytokines, orexigenic and anorexigenic peptides) only cytokines have differentiated two type of AN. IL6R, IL6ST, IL1B, IL2RB and TGFB1 differentiate two type of AN: the restrictive type of AN and binge-eating type of AN. IL1B differentiates the restrictive type of AN and the reference group and TGFB1, IL6ST and IL1B differentiate the binge-eating type of AN and the reference group.

Conclusion:

Orexigenic and anorexigenic peptides are responsible for eating behavior but not for food intake.

Type
Poster Session I: Biological Markers
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S172 - S173
Copyright
Copyright © European Psychiatric Association 2008
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