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P0248 - A family case study on schizophrenia and bipolar disorder: Genotype and Cognition

Published online by Cambridge University Press:  16 April 2020

A.M. Zaharie ,
I. Miclutia ,
M. Fadgyas Stanculete ,
E. Ergul  and
A. Sazci
A.M. Zaharie
Affiliation:
Psychiatry Department, Emergency Clinical County Hospital, Cluj Napoca, Romania
I. Miclutia
Affiliation:
Department of Psychiatry, Universitity of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
M. Fadgyas Stanculete
Affiliation:
Department of Psychiatry, Universitity of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
E. Ergul
Affiliation:
Faculty of Medicine, Department of Medical Biology, University of Kocaeli, Umuttepe, Turkey
A. Sazci
Affiliation:
Faculty of Medicine, Department of Medical Biology, University of Kocaeli, Umuttepe, Turkey

Abstract

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Schizophrenia and bipolar disorder represent serious mental disorders with polygenic inheritance. Neurocognitive deficits have been linked to psychotic phenomena and are candidate endophenotype for the illness. We have analyzed the case of a family consisting of mother diagnosed with bipolar disorder, a daughter with schizophrenia and one free of psychiatric disorders. The genetic associations between a functional polymorphism in the MTHFR, COMT, APOE and MnSOD genes and cognition have been investigated. Genotyping was carried out using a PCR-RFLP method. Neuropsychological tests regarding executive functions (WCST, TMT-B), memory (RAVLT), attention (TMT-A) and phonetic and semantic verbal fluency have been applied. No significant association was found.

Type
Poster Session I: Schizophrenia and Psychosis
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S153 - S154
Copyright
Copyright © European Psychiatric Association 2008
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