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P02-377 - Antidepressants And Group Psychosocial Treatment For Depression: An Rct From A Low Income Country

Published online by Cambridge University Press:  17 April 2020

N. Husain ,
N. Chaudhry ,
B. Fatima ,
M. Husain ,
R. Amin ,
I.B. Chaudhry ,
R.U. Rahman ,
S.U. Haq ,
F. Jaffery  and
F. Creed
N. Husain
Affiliation:
University of Manchester, Manchester, UK
N. Chaudhry
Affiliation:
University of Manchester, Manchester, UK
B. Fatima
Affiliation:
Pakistan Institute of Learning and Living, Karachi, Pakistan School of Public Health, Boston University, Boston, MA, USA
M. Husain
Affiliation:
Lancashire Care NHS Foundation Trust, Manchester, UK
R. Amin
Affiliation:
Pakistan Institute of Learning and Living, Karachi, Pakistan
I.B. Chaudhry
Affiliation:
University of Manchester, Manchester, UK
R.U. Rahman
Affiliation:
Department of Psychiatry, Dow Medical College Karachi, Karachi, Pakistan
S.U. Haq
Affiliation:
Statistician, Pakistan Institute of Learning & Living, Karachi, Pakistan
F. Jaffery
Affiliation:
Department of Community Medicine, Karachi Medical & Dental College, Karachi, Pakistan
F. Creed
Affiliation:
University of Manchester, Manchester, UK

Abstract

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Background

Depression is a global public health problem with highest rates in women in low income countries including Pakistan. There are no treatment trials from such countries comparing the efficacy of antidepressant treatment with a group psychological intervention.

Methods

We conducted a preliminary RCT in an urban primary care clinic in Karachi, Pakistan. Consecutive eligible women scoring > 12 on the CIS-R and > 18 on HDRS (n=66) were randomly assigned to antidepressant or group psychosocial treatment. The primary outcome measure was HDRS score; secondary outcome measures were disability and quality of life.

Results

96% patients were assessed at 3 & 6 months after baseline. At 6 months response (50% reduction of HDRS score) occurred in 20 (60.6%) and 22(66.7%) of the psychosocial and antidepressant groups respectively. There was also significant reduction in disability and improvement in health related quality of life in both groups.

Conclusion

Low costs antidepressants and group psychosocial treatment on the principles of CBT merit further assessment as primary treatments for depression in low income countries.

Type
Women's mental health
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E1379
Copyright
Copyright © European Psychiatric Association 2010
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