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P0189 - Plasma antioxidants in schizophrenia and manic relapse

Published online by Cambridge University Press:  16 April 2020

D. Kontis ,
R.M. Psaras ,
E. Lia ,
S. Papadopoulos ,
E. Baka ,
S. Makri  and
C. Karouzos
D. Kontis
Affiliation:
1st Psychiatric Department, Psychiatric Hospital of Attica, Athens, Greece
R.M. Psaras
Affiliation:
1st Psychiatric Department, Psychiatric Hospital of Attica, Athens, Greece
E. Lia
Affiliation:
1st Psychiatric Department, Psychiatric Hospital of Attica, Athens, Greece
S. Papadopoulos
Affiliation:
1st Psychiatric Department, Psychiatric Hospital of Attica, Athens, Greece
E. Baka
Affiliation:
1st Psychiatric Department, Psychiatric Hospital of Attica, Athens, Greece
S. Makri
Affiliation:
1st Psychiatric Department, Psychiatric Hospital of Attica, Athens, Greece
C. Karouzos
Affiliation:
1st Psychiatric Department, Psychiatric Hospital of Attica, Athens, Greece

Abstract

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Background:

There is evidence of an abnormal antioxidant defence system in schizophrenia. No such evidence exists for bipolar disorder.

Aim:

To compare plasma antioxidant levels between patients with a relapse of schizophrenia or bipolar disorder (manic episode).

Methods:

The serum levels of uric acid and bilirubin were assessed in 160 patients with schizophrenia and 41 patients with bipolar disorder, consecutively admitted in an acute psychiatric ward during a 2-year period.

Results:

Uric acid plasma levels were lower in patients with schizophrenia compared to bipolar patients (p=0.024), after adjusting for age. This difference was observed in male patients, while no significant difference was noted in females. The two groups did not significantly differ in plasma bilirubin concentrations. In patients with schizophrenia, uric acid concentrations positively correlated with bilirubin levels (Spearman rho=0.205, p=0.012), while no correlation between these two antioxidants was found in bipolar patients.

Conclusions:

Our findings suggest that acutely admitted patients with schizophrenia have lower plasma uric acid levels, but do not differ in bilirubin levels compared to bipolar patients.

Type
Poster Session I: Schizophrenia and Psychosis
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S136 - S137
Copyright
Copyright © European Psychiatric Association 2008
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