The features of atypical neuroleptics influence on immune parameters and aspartate and alanine aminotransferases blood serum level of schizophrenics during 6-week therapy.

We examined 52 schizophrenics: 20 patients were treated by quetiapine, 12 - by olanzapine, 10 - by rispolept, 10 - by amisulpride. Scales PANSS and CGI was used at clinical examination. We defined the parameters of cellular, humoral immunity, serum levels of aminotransferases. Control group – 36 healthy people.

The data of favorable influence on positive, negative, general psychopathological symptoms of patients was observed.

Before therapy T-cell immunodeficiency with reduction of CD2+-, CD4+-, CD16+-cells was observed among schizophrenics (comparing to control). Authentically high aminotransferases levels in first point were observed in groups of patients treated by olanzapine and quetiapine.

During 6 weeks of quetiapine treatment indices of аHLA-DR+-cells quantity, CD16+-cells, IgA, IC level tend to those of control indices, the normalization of aminotransferases levels was observed.

During olanzapine treatment the normalization of CD2+-, CD8+-cells was observed; we determined the increase of IgА and IgM in the process of normalization of IgG and IC level. Aminotransferases levels reduced up to control indices.

During rispolept treatment the normalization of lymphocytes, CD4+-, CD16+-cells, was observed; during amisulpride treatment the reduction of CD2+-, аHLA-DR+-lymphocytes the increase of IC level, the normalization of CD16+-cells quantity and the increase of aminotransferases levels was revealed.

Summary: Was observed priority data about render various effects on immune parameters of atypical neuroleptics; dynamics of aminotransferases level which depends on their initial level is revealed.