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The OPUS trial: Transition from schizotypal disorder to psychotic disorder. A RCT of integrated treatment and standard treatment

Published online by Cambridge University Press:  16 April 2020

M. Nordentoft ,
A. Thorup ,
P. Jeppesen ,
L. Petersen ,
J. Øhlenschlæger ,
G. Krarup ,
T. Christensen  and
P. Jørgensen
M. Nordentoft
Affiliation:
Bispebjerg Hospital, Copenhagen University, Copenhagen, Denmark
A. Thorup
Affiliation:
Bispebjerg Hospital, Copenhagen University, Copenhagen, Denmark
P. Jeppesen
Affiliation:
Bispebjerg Hospital, Copenhagen University, Copenhagen, Denmark
L. Petersen
Affiliation:
Bispebjerg Hospital, Copenhagen University, Copenhagen, Denmark
J. Øhlenschlæger
Affiliation:
SCT Hans Hospital, Roskilde, Denmark
G. Krarup
Affiliation:
Psychiatric Hospital Risskov, Aarhus, Denmark
T. Christensen
Affiliation:
Psychiatric Hospital Risskov, Aarhus, Denmark
P. Jørgensen
Affiliation:
Psychiatric Hospital Risskov, Aarhus, Denmark

Abstract

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Background

Only a few randomized clinical trials have tested the effect on transition rates of intervention programs for patients with sub-threshold psychosis-like symptoms.

Aim

To examine whether integrated treatment reduced transition to psychosis for first-contact patients diagnosed with schizotypal disorder.

Methods

Seventy-nine patients were randomized to integrated treatment or standard treatment. Survival analysis with multivariate Cox-regression was used to identify factors determinant for transition to psychotic disorder.

Results

In the multivariate model, male gender increased risk for transition to psychotic disorder (relative risk = 4.47, (confidence interval 1.30-15.33)), while integrated treatment reduced the risk (relative risk = 0.36 (confidence interval 0.16-0.85)). At two-year follow-up, the proportion diagnosed with a psychotic disorder was 25.0 percent for patients randomized to integrated treatment compared to 48.3 percent for patients randomized to standard treatment.

Conclusion

Integrated treatment postponed or inhibited onset of psychosis in significantly more cases than standard treatment.

Type
S47. Symposium: Prodrome-Based Early Intervention in the Course of Schizophrenia
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S76
Copyright
Copyright © European Psychiatric Association 2007
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