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Neurofibromatosis type 1 comorbid with attention deficit and hyperactivity disorder. Case report

Published online by Cambridge University Press:  01 September 2022

P. Del Sol Calderón ,
R. Paricio Del Castillo ,
L. Mallol Castaño ,
A. Izquierdo De La Puente  and
M. Garcia Moreno
P. Del Sol Calderón*
Affiliation:
Hospital Universitario Puerta de Hierro, Psiquiatría Infanto-juvenil, Madrid, Spain
R. Paricio Del Castillo
Affiliation:
Hospital Universitario Puerta de Hierro, Psiquiatría Infanto-juvenil, Madrid, Spain
L. Mallol Castaño
Affiliation:
Hospital Universitario Puerta de Hierro, Psiquiatría Infanto-juvenil, Madrid, Spain
A. Izquierdo De La Puente
Affiliation:
HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA, Psychiatry, MADRID, Spain
M. Garcia Moreno
Affiliation:
HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA, Psychiatry, MADRID, Spain
*
*Corresponding author.

Abstract

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Introduction

A 9-year-old girl under pediatric follow-up since the age of 4 years after diagnosis of neurofibromatosis type 1

Objectives

To present a case of neurofibromatosis and ADHD comorbidity to raise awareness of the importance of screening for neurodevelopmental disorders.

Methods

Case report and literature review

Results

The patient had an adequate control and follow-up of the disorder with periodic check-ups and magnetic resonance imaging during her follow-up. She was referred due to symptoms of inattention with failure to perform exams and impulsivity in interpersonal relationships, affecting her social functioning. In addition, the patient presented simple motor tics of eye contraction and shoulder elevation. The patient was diagnosed with attention deficit hyperactivity disorder together with tic disorder. She was treated with stimulant medication with worsening of tics and marked hyporexia. Therefore, medication with guanfacine was started up to 4 mg per day, adjusted by weight. With this dose there was a control of the tics, with improvement of the symptoms of inattention and impulsivity. In different spheres an improvement in their functionality was observed, with improvement in mood, self-esteem and academic performance.

Conclusions

Neurofibromatosis type 1 is a rare monogenic disorder with a varied presentation (ophthalmologic, dermatologic and predisposition to tumor development). Patientshave been shown to present with symptoms of inattention and executive function impairment, along with other neurodevelopmental disorders such as autism spectrum disorders, learning disabilities or intellectual disability. The literature shows that up to 60% of them has ADHD criteria.

Disclosure

No significant relationships.

Keywords

neurofibromatosisADHDTICSComorbidity
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S431
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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