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Neurocognitive status in different stages of psychosis: Changes from the first episode psychosis to remission

Published online by Cambridge University Press:  23 March 2020

D. Bošnjak
Affiliation:
University Psychiatric Hospital Vrapce, First Psychosis Unit, Zagreb, Croatia
P. Makarić
Affiliation:
University Psychiatric Hospital Vrapce, The Addictions Department, Zagreb, Croatia
I. Kekin
Affiliation:
Zagreb University Hospital Centre, Department of Psychiatry, Zagreb, Croatia
T. Sabo
Affiliation:
University Psychiatric Hospital Vrapce, Psychogeriatrics Department, Zagreb, Croatia
M. Živković
Affiliation:
University Psychiatric Hospital Vrapce, Department of Psychotic Disorders, Zagreb, Croatia
A. Savić
Affiliation:
University Psychiatric Hospital Vrapce, First Psychosis Unit, Zagreb, Croatia
A. Silić
Affiliation:
University Psychiatric Hospital Vrapce, First Psychosis Unit, Zagreb, Croatia
I. Čulo
Affiliation:
University Psychiatric Hospital Vrapce, First Psychosis Unit, Zagreb, Croatia
D. Ostojić
Affiliation:
University Psychiatric Hospital Vrapce, First Psychosis Unit, Zagreb, Croatia
V. Jukić
Affiliation:
University Psychiatric Hospital Vrapce, Forensics Department, Zagreb, Croatia
M. Rojnić Kuzman
Affiliation:
Zagreb University Hospital Centre, Department of Psychiatry, Zagreb, Croatia

Abstract

Introduction

Neurocognitive impairment in schizophrenia is associated with functional disability and poorer quality of life, and is the most resistant of all schizophrenia symptoms to current psychopharmacotherapy.

Objectives

To compare the differences in neurocognitive status during the acute phase of first psychotic episode and stable symptomatic remission.

Aims

To investigate the pattern of neurocognitive impairment in patients with first episode psychosis during acute phase and stable remission phase.

Methods

We performed a longitudinal study, including 150 patients with first episode of psychosis at two time points: during their hospitalization at Zagreb university hospital centre or university psychiatric hospital Vrapče, at acute phase of illness and after 12–18 months, during stable remission. Assessment included detailed clinical interview, clinical rating of neuropsychiatric symptoms using standardized psychiatric scales, self-assessment scales and comprehensive neurocognitive testing.

Results

While our preliminary results (n = 40) showed statistically significant improvement in various neurocognitive domains, including visuo-learning abilities, verbal learning, executive functions, attention and processing speed, initial impairment in semantic and phonetic fluency observed in acute psychosis remained unchanged in remission as well.

Conclusions

Although our results showed improvement in most of cognitive domains during time, language abilities remained unchanged. This further confirms the hypothesis that language impairment is a trait marker of psychotic disorder.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster walk: Schizophrenia and other psychotic disorders–part 1
Copyright
Copyright © European Psychiatric Association 2017
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