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Longitudinal effects of antidepressant treatment on resting state functional connectivity in adolescents with major depressive disorder

Published online by Cambridge University Press:  01 September 2022

K.H. Lee ,
J. Shin ,
J. Lee ,
J.H. Yoo  and
J.-W. Kim
K.H. Lee*
Affiliation:
Seoul National University Hospital, Division Of Child And Adolescent Psychiatry, Department Of Psychiatry, Seoul, Korea, Republic of
J. Shin
Affiliation:
Seoul National University Hospital, Division Of Child And Adolescent Psychiatry, Department Of Psychiatry, Seoul, Korea, Republic of
J. Lee
Affiliation:
Seoul National University Children’s Hospital, Integrative Care Hub, Seoul, Korea, Republic of
J.H. Yoo
Affiliation:
Seoul ST. Mary’s Hospital, Department Of Psychiatry, Seoul, Korea, Republic of
J.-W. Kim
Affiliation:
Seoul National University Hospital, Division Of Child And Adolescent Psychiatry, Department Of Psychiatry, Seoul, Korea, Republic of
*
*Corresponding author.

Abstract

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Introduction

Adolescents with major depressive disorder (MDD) often show reduced prefrontal functional connectivity with the subcortical regions than healthy controls (HC) (Tang et al., 2018). However, relatively little is known about longitudinal effects of antidepressant (AD) treatment on resting state functional connectivity (RSFC) in the prefrontal cortex (PFC).

Objectives

This study aimed to investigate abnormal PFC RSFC in MDD adolescents compared to HC and longitudinal effects of AD on PFC RSFC.

Methods

This study included 59 adolescents with MDD and 43 HC. MDD adolescents were treated with escitalopram in an 8 week, open-label trial. The treatment outcome was assessed by Children’s Depression Rating Scale (CDRS-R) and patients showing at least a 40% improvement in CDRS-R scores from baseline to week 8 were defined as “responders”. Functional and T1 images collected before and after treatment were processed using AFNI and Freesurfer. Our seed was the lateral PFC (LPFC, BA46). T-tests and repeated measures ANCOVAs, controlling for age and IQ, were conducted to examine abnormal PFC RSFC and longitudinal effects of AD on LPFC RSFC.

Results

Relative to HC, MDD showed increased LPFC RSFC with the posterior middle temporal gyrus (pMTG) and superior frontal cortex (SFG) involved in attentional networks. Responders showed greater changes in LPFC RSFC with the MTG and SFG after AD treatment compared to non-responders and HC (Figure 1).

Conclusions

Our finding suggests that reduced LPFC RSFC with the pMTG and SFG reflecting decreased attentional network connectivity may serve as a biomarker to predict AD treatment outcome in adolescents with MDD.

Disclosure

No significant relationships.

Keywords

adolescencemajor depressive disorderresting-state functional connectivityantidepressant treatment
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S85
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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