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Lithium: Managing Cognitive Impairment and Sexual Problems

Published online by Cambridge University Press:  19 July 2023

J. Petta ,
A. L. Falcão ,
G. Soares  and
A. Lourenço
J. Petta*
Affiliation:
Centro Hospitalar Psiquiátrico de Lisboa, Lisboa, Portugal
A. L. Falcão
Affiliation:
Centro Hospitalar Psiquiátrico de Lisboa, Lisboa, Portugal
G. Soares
Affiliation:
Centro Hospitalar Psiquiátrico de Lisboa, Lisboa, Portugal
A. Lourenço
Affiliation:
Centro Hospitalar Psiquiátrico de Lisboa, Lisboa, Portugal
*
*Corresponding author.

Abstract

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Introduction

Patients taking lithium complain of cognitive impairment. This was assumed to be real by expert clinicians for years until relatively recent objective neuropsychological studies have failed to verify much impairment.

Second and perhaps underemphasized side effect from lithium is sexual dysfunction.

Objectives

The objective of this review is to highlight for the cognitive and sexual problems, which are two very important areas for discussion with patients. It should be brought up right when beginning to prescribe.

Methods

Data was obtained through an internet-based literature review, using the research platform PubMed and the World Health Organization website. Eight articles from the last five years were included.

Results

Due to the lack of evidence in neuropsychological studies, what was considered to be impaired cognitive function in the past has been recently considered a loss of sharp thinking in manic states or mild persisting depressions.

About sexual dysfunction it is important eliminating other possible causes, lowering lithium dose, timing sex, and taking sildenafil and 240 mg/day of aspirin may help.

Conclusions

Cognitive impairment and sexual problems are two important subjects that involve the issues of dosing, of managing and dealing with people’s willingness to take lithium.

Providing psychoeducation about these possible effects can head off abrupt discontinuation impulses.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S1009
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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