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Is the Molecular Clock Ticking Differently in Bipolar Disorder?

Published online by Cambridge University Press:  15 April 2020

S. Bengesser ,
N. Lackner ,
A. Birner ,
B. Reininghaus ,
U. Heilbronner ,
R. Fuchs ,
N. Allard ,
S. Wallner-Liebmann ,
A. Rieger  and
R. Queissner
...Show all authors
S. Bengesser
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
N. Lackner
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
A. Birner
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
B. Reininghaus
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
U. Heilbronner
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
R. Fuchs
Affiliation:
Pathophysiology, Medical University of Graz, Graz, Austria
N. Allard
Affiliation:
Pathophysiology, Medical University of Graz, Graz, Austria
S. Wallner-Liebmann
Affiliation:
Pathophysiology, Medical University of Graz, Graz, Austria
A. Rieger
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
R. Queissner
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
K. Filic
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
F. Fellendorf
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
E. Petek
Affiliation:
Human Genetics, Medical University of Graz, Graz, Austria
C. Windpassinger
Affiliation:
Human Genetics, Medical University of Graz, Graz, Austria
C. Schörkhuber
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
C. Gigler
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
K. Gatkowsky
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
T. Macheiner
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
N. Kainzbauer
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria
E. Reininghaus
Affiliation:
Psychiatry, Medical University of Graz, Graz, Austria

Abstract

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Introduction

Bipolar Disorder is a devastating disease with a genetic heritability. An orchestra of around 500 gene variants is leading to vulnerability.

One interesting candidate gene group are the socalled CLOCK GENES. The molecular 24h clock has several CLOCK GENES and the last gene ARNTL encodes for an activator of MAOA transcription and leads therefore to changes in neurotransmitter levels.

Methods

Genotyping of 150 paricipants with Bipolar Disorder and 78 healthy controls with the Illumina GWAS chip Omniexpress 1.1. Hypothesis driven extraction of ARNTL SNPs with the software PLINK. Statistical analysis with Chi square test with SPSS.

Results

Patients with Bipolar Disorder differ significantly in ARNTL genotypes compared to healthy controls. Details are presented during the poster session.

Discussion

Circadian rhythms seem to play an important pathogenetic mechanism in Bipolar Disorder.

Type
Article: 0557
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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