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Indicated Prevention in Clinical High Risk (Chr) for First Episode Psychosis (Fep): the Utility of an Extended Diagnostic Approach.

Published online by Cambridge University Press:  15 April 2020

B. Baune
Affiliation:
Discipline of Psychiatry, University of Adelaide, Adelaide, Australia
O. Schubert
Affiliation:
Discipline of Psychiatry, University of Adelaide, Adelaide, Australia
S. Clark
Affiliation:
Discipline of Psychiatry, University of Adelaide, Adelaide, Australia

Abstract

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Introduction

The concept of indicated prevention has proliferated in psychiatry. Accumulating evidence suggests that it may indeed be possible to prevent or delay the onset of a First Episode of Psychosis (FEP) though adequate interventions in individuals deemed at Clinical High Risk (CHR) for such an event. However, a challenge undermining these efforts is the relatively poor predictive accuracy of clinical assessments used in practice for CHR individuals. to improve prediction by combining different types of assessments.

Objectives

To improve prediction of clinical course of disease by combining biological and clinical types of assessment.

Aims

To present a probabilistic prediction model containing clinical and biological data for the transition to first episode psychosis.

Methods

Using data from published studies, and employing predictive models based on the odds ratio form of Bayes’ rule, we simulated scenarios where clinical interview, neurocognitive testing, structural magnetic resonance imaging (MRI) and electrophysiology are part of the initial assessment process of a CHR individual (Extended Diagnostic Approach).

Results

Our findings indicate that for most at-risk patients, at least three types of assessments are necessary to arrive at a clinically meaningful differentiation into high- intermediate-, and low-risk groups. In particular, patients with equivocal results in the initial assessments require additional diagnostic testing to produce an accurate risk profile forming part of the comprehensive initial assessment.

Conclusions

The findings may inform future research into reliable identification and personalized therapeutic targeting of CHR patients, to prevent transition to full-blown psychosis and to inform decision in intervention.

Type
Article: 0806
Copyright
Copyright © European Psychiatric Association 2015
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