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The impact of sexual hormones on depressive symptoms and alcohol use in a woman with delusional disorder at the perimenopausal stage: case report and review of recent works

Published online by Cambridge University Press:  01 September 2022

G.F. Fucho ,
L. Delgado ,
A. González-Rodríguez ,
A. Guàrdia ,
A. Álvarez ,
S. Crivillés ,
J.D. Barbero ,
J.A. Monreal ,
J. Labad  and
D. Palao Vidal
G.F. Fucho*
Affiliation:
Parc Taulí University Hospital, Department Of Mental Health, Sabadell, Barcelona, Spain
L. Delgado
Affiliation:
Parc Taulí University Hospital, Department Of Mental Health, Sabadell, Barcelona, Spain
A. González-Rodríguez
Affiliation:
Mutua Terrassa University Hospital, Department Of Mental Health, Terrassa, Spain
A. Guàrdia
Affiliation:
Mutua Terrassa University Hospital, Department Of Mental Health, Terrassa, Spain
A. Álvarez
Affiliation:
Mutua Terrassa University Hospital, Department Of Mental Health, Terrassa, Spain
S. Crivillés
Affiliation:
Parc Taulí University Hospital, Department Of Mental Health, Sabadell, Barcelona, Spain School of Medicine, Universitat Autònoma de Barcelona, Medicine, Cerdanyola del Vallés, Spain
J.D. Barbero
Affiliation:
Parc Taulí University Hospital, Department Of Mental Health, Sabadell, Barcelona, Spain School of Medicine, Universitat Autònoma de Barcelona, Medicine, Cerdanyola del Vallés, Spain
J.A. Monreal
Affiliation:
Mutua Terrassa University Hospital, Department Of Mental Health, Terrassa, Spain School of Medicine, Universitat Autònoma de Barcelona, Medicine, Cerdanyola del Vallés, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Salud Mental, Madrid, Spain
J. Labad
Affiliation:
School of Medicine, Universitat Autònoma de Barcelona, Medicine, Cerdanyola del Vallés, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Salud Mental, Madrid, Spain Hospital of Mataró, Consorci Sanitari Del Maresme, Mataró, Spain
D. Palao Vidal
Affiliation:
Parc Taulí University Hospital, Department Of Mental Health, Sabadell, Barcelona, Spain School of Medicine, Universitat Autònoma de Barcelona, Medicine, Cerdanyola del Vallés, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Salud Mental, Madrid, Spain
*
*Corresponding author.

Abstract

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Introduction

The influence of sexual hormones on mental disorders have been extensively reported. In fact, recent studies suggest that sex hormones may play a relevant role in the pathophysiology of psychosis, may be a precipitant when exogenously administered or even be used as a treatment agent of psychotic disorders.

Objectives

To describe the case of a patient with a recent diagnosis of delusional disorder (DD) with an onset in the perimenopausal period.

Methods

Case report and narrative review focused on the impact of sexual hormones on depressive symptoms and alcohol use comorbidity during perimenopause in DD women by using PubMed database.

Results

Case report: A 48-year-old woman diagnosed with DD. The clinical assessment of climacteric symptoms, as well as the gonadotropins (elevated levels of follicle-stimulating hormone -FSH- and luteinizing hormone -LH-) and estrogen levels monitoring (variations on 17-β-estradiol -E2-) enabled to link the endocrine changes with the onset and course of the psychiatric disorder. During the development of the disease, the patient also presented comorbid depressive symptoms and alcohol use disorder. Review: Estrogen depletion seems to increase the risk of psychosis, while scientific literature is not conclusive in establishing a definitive relationship between depressive symptoms and hormonal imbalance in DD. Alcohol use disorder is a common comorbidity in both perimenopausal women and patients with DD.

Conclusions

Multiaxial management of the case helped clinicians to achieve clinical stabilization. Sex differences as well as hormonal pattern disturbances should receive special attention due to the seminal implications in pharmacotherapy and clinical outcomes.

Disclosure

No significant relationships.

Keywords

Delusional disorderDepressionAlcohol usesexual hormones
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S863
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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