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Immune-related genes are differentially associated with negative symptoms subdomains in patients with schizophrenia

Published online by Cambridge University Press:  01 September 2022

V. Golimbet ,
T. Lezheiko ,
G. Korovaitseva ,
N. Kolesina ,
V. Plakunova  and
V. Mikhailova
V. Golimbet*
Affiliation:
Mental Health Research Center, Clinical Genetics Laboratory, Moscow, Russian Federation
T. Lezheiko
Affiliation:
Mental Health Research Center, Clinical Genetics Laboratory, Moscow, Russian Federation
G. Korovaitseva
Affiliation:
Mental Health Research Center, Clinical Genetics Laboratory, Moscow, Russian Federation
N. Kolesina
Affiliation:
Mental Health Research Center, Clinical Genetics Laboratory, Moscow, Russian Federation
V. Plakunova
Affiliation:
Mental Health Research Center, Clinical Genetics Laboratory, Moscow, Russian Federation
V. Mikhailova
Affiliation:
Mental Health Research Center, Clinical Genetics Laboratory, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Negative symptoms (NS) are a core feature of schizophrenia. NS show heterogeneity proven by factor analysis, which revealed two distinct negative symptoms subdomains: diminished expression (DE) and avolition/apathy (AA) (Marder et al. 2017, Fleischhacker et al. 2019). Some studies showed the different effects of these subdomains on clinical features of schizophrenia that suggest different pathophysiological mechanisms for their development (Stanculete 2021). It has been also shown that the levels of peripheral interleukins (IL) specifically correlate with NS (Enache et al. 2021), in particular, increased IL levels were determined in patients with deficit syndrome compared to non-deficit schizophrenia (Goldsmith et al. 2018).

Objectives

To search for the association of genes for IL-4, IL-6, IL-10 and C-reactive protein (CRP) with NS subdomains.

Methods

The total sample included 551 patients (women 51,4%, aged 18-72 years) with ICD-10 diagnosis of schizophrenia. NS were assessed by PANSS. PANSS-derived factors include AA (items N2, N4, G16) and DE (N1, N3, N6, G5, G7, G13). Genotyping was performed for the following polymorphisms: C-589T IL-4, C-174G IL-6, C-592A IL-10, G-1082A IL-10, CRP (rs2794521).

Results

There are effects of C-592A IL-10 (p=0.017) and G-1082A IL-10 (p=0.012) on AA subdomain. Post-hoc Bonferroni corrected comparisons show that carriers of the haplotype AA (C-592A)- AA (G-1082A) have the highest AA score. A significant effect of CRP (rs2794521) on AA is identified (p=0.007). There is a trend towards the association of C-589T IL-4 and C-174G IL-6 with AA. No association of these polymorphisms with DE was found.

Conclusions

AA and DE may have different genetic background.

Disclosure

No significant relationships.

Keywords

immune-related genesnegative symptomsschizophrénia
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S286
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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