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Heart Rate Variability and Omega-3 Index in Euthymic Patients with Bipolar Disorders

Published online by Cambridge University Press:  15 April 2020

A. Voggt ,
M. Berger ,
M. Obermeier ,
A. Löw ,
F. Seemueller ,
M. Riedel ,
H.J. Moeller ,
R. Zimmermann ,
F. Kirchberg  and
C. Von Schacky
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A. Voggt
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany
M. Berger
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany Klinik für Psychiatrie und Psychotherapie, Clienia Schlössli, Oetwil am See, Switzerland
M. Obermeier
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany GKM Gesellschaft für Therapieforschung mbH, Munich, Germany
A. Löw
Affiliation:
Department of Internal Medicine, Ludwig-Maximilians-Universität München, Munich, Germany
F. Seemueller
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany Klinik für Psychiatrie, Psychotherapie und Psychosomatik, kbo-Lech-Mangfall-Klinik Garmisch-Partenkirchen, Garmisch-Partenkirchen, Germany
M. Riedel
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany Vinzenz-von-Paul-Hospital, Rottweil, Germany
H.J. Moeller
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany
R. Zimmermann
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany Klinik für Psychiatrie, Psychotherapie und Psychosomatik, kbo-Lech-Mangfall-Klinik Garmisch-Partenkirchen, Garmisch-Partenkirchen, Germany
F. Kirchberg
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany Dr. von Haunersches Kinderspital, Ludwig-Maximilians-Universität München, Munich, Germany
C. Von Schacky
Affiliation:
Department of Preventive Cardiology, Ludwig-Maximilians-Universität München, Munich, Germany
E. Severus*
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Germany
*
*Corresponding author. Fetscherstraޥ 74, 01307 Dresden, Germany. Tel.: +49 351 4583780. E-mail address:emanuel.severus@uniklinikum-dresden.de (E. Severus).
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Abstract

Background:

Affective disorders are associated with an increased risk of cardiovascular disease, which, at least partly, appears to be independent of psychopharmacological treatments used to manage these disorders. Reduced heart rate variability (SDNN) and a low Omega-3 Index have been shown to be associated with increased risk for death after myocardial infarction. Therefore, we set out to investigate heart rate variability and the Omega-3 Index in euthymic patients with bipolar disorders.

Methods:

We assessed heart rate variability (SDNN) and the Omega-3 Index in 90 euthymic, mostly medicated patients with bipolar disorders (Bipolar-I, Bipolar-II) on stable psychotropic medication, free of significant medical comorbidity and in 62 healthy controls. Heart rate variability was measured from electrocardiography under a standardized 30 minutes resting state condition. Age, sex, BMI, smoking, alcohol consumption and caffeine consumption as potential confounders were also assessed.

Results:

Heart rate variability (SDNN) was significantly lower in patients with bipolar disorders compared to healthy controls (35.4 msec versus 60.7 msec; P < 0.0001), whereas the Omega-3 Index did not differ significantly between the groups (5.2% versus 5.3%). In a linear regression model, only group membership (patients with bipolar disorders versus healthy controls) and age significantly predicted heart rate variability (SDNN).

Conclusion:

Heart rate variability (SDNN) may provide a useful tool to study the impact of interventions aimed at reducing the increased risk of cardiovascular disease in euthymic patients with bipolar disorders. The difference in SDNN between cases and controls cannot be explained by a difference in the Omega-3 Index.

Keywords

Bipolar disorderHeart rate variabilityOmega-3 IndexCardiovascular disease
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 2 , February 2015 , pp. 228 - 232
Copyright
Copyright © Elsevier Masson SAS 2014

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