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A functional SNP in MIR124-1, a brain expressed miRNA gene, is associated with aggressiveness in a Colombian sample

Published online by Cambridge University Press:  15 April 2020

Y. González-Giraldo ,
A. Camargo ,
S. López-León ,
A. Adan  and
D.A. Forero
Y. González-Giraldo
Affiliation:
Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia
A. Camargo
Affiliation:
School of Nursing, Universidad de Ciencias Aplicadas y Ambientales UDCA, Bogotá, Colombia
S. López-León
Affiliation:
Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
A. Adan
Affiliation:
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain Institute for Brain, Cognition and Behavior (IR3 C), Barcelona, Spain
D.A. Forero*
Affiliation:
Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia
*
*Corresponding author. Tel.: +57 313 2610427. E-mail address:diego.forero@uan.edu.co (D.A. Forero).
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Abstract

Background:

Interpersonal violence and suicide are among the main causes of mortality and morbidity around the world. In several developing countries, such as Colombia, they are among the first five entities of public health concern. Aggressiveness is an important endophenotype for aggression and suicidal behavior, having a heritability of around 50%. Exploration of classical candidate genes, involved in serotoninergic and dopaminergic neurotransmission, has identified few consistent risk factors for aggressiveness. miRNAs are a novel class of molecules with a growing role in normal neural function and neuropsychiatric disorders; of special interest, miR-124 is a brain-specific miRNA that is key for neuronal plasticity. We evaluated the hypothesis that a functional polymorphism in MIR124-1 gene might be associated with aggressiveness in a Colombian sample.

Methods:

The Spanish adaptation of the refined version of the Aggression Questionnaire and the abbreviated Barratt Impulsiveness Scale were applied to 170 young subjects. The functional SNP in MIR124-1 (rs531564) was genotyped by a TaqMan assay.

Results:

We found a significant association between the MIR124-1 and aggressiveness in our sample, with G/G carriers having lower scores (P = 0.01). This association seemed to be specific for aggressiveness, as it was not significant for impulsiveness.

Conclusions:

We showed for the first time the association of a functional polymorphism in MIR124-1 and aggressiveness. Known targets of miR-124 (such as BDNF and DRD4 genes) could explain the effect of this miRNA on behavior. A future analysis of additional novel functional polymorphisms in other brain expressed miRNAs could be useful for a deeper understanding of aggression in humans.

Keywords

AggressionEndophenotypesLatin AmericancRNAsPsychiatric geneticsViolence
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 4 , June 2015 , pp. 499 - 503
Copyright
Copyright © Elsevier Masson SAS 2015

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Footnotes

Abbreviations: BDNF, brain-derived neurotrophic factor; GABBR2, gamma-aminobutyric acid B receptor 2; DRD4, dopamine receptor D4; SLITRK4, SLIT and NTRKlike family member 4; SNAP23, synaptosomal-associated protein 23 kDa; RGS4, regulator of G-protein signaling 4; VAMP3, vesicle-associated membrane protein 3; ROBO3, roundabout, axon guidance receptor, homolog 3; ASW, African ancestry in Southwest USA; CEU, Northern Europeans from Utah, USA; CHB, Han Chinese in Beijing, China; CHD, Chinese in Denver, USA; CLB, Colombians in Bogotá, Colombia; GIH, Gujarati Indians in Houston, Texas; JPT, Japanese in Tokyo, Japan; LWK, Luhya in Webuye, Kenya; MXL, Mexican ancestry in Los Angeles, USA; MKK, Maasai in Kinyawa, Kenya; TSI, Toscani in Italia; YRI, Yoruba in Ibadan, Nigeria.

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