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Frontostriatal Dysconnectivity in adolescent Onset Schizophrenia and its Associations with Cognition: An MRI Volumetric and Diffusion Tensor Imaging Study

Published online by Cambridge University Press:  23 March 2020

A. James ,
H.M. Fernandes ,
P. Alves Da Mota  and
M. Hough
A. James
Affiliation:
Oxford University, Psychiatry, Oxford, United Kingdom
H.M. Fernandes
Affiliation:
Aarhus University, Department of Clinical Medicine, Center for Music In the Brain, Aarhus, Denmark
P. Alves Da Mota
Affiliation:
Aarhus University, Department of Clinical Medicine, Center for Music In the Brain, Aarhus, Denmark
M. Hough
Affiliation:
University of Oxford, FMRIB, Oxford, United Kingdom

Abstract

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Background

Adolescent-onset schizophrenia (AOS) is associated with cognitive impairment and poor clinical outcome. Cognitive dysfunction is thought to reflect functional dysconnectivity between the frontal cortex and the striatum, Previous work [1] has shown frontostriatal dysconnectivity in large WM tracts explain core cognitive deficits, with processing speed, which is affected by alterations in WM connectivity, being an intermediary variable.

Objective

To undertake a follow-up MRI study using whole-brain structural connectomics to track topological changes in the follow-up (1st episode versus follow-up), in order to characterize the early stages (evolution of the first two years) of the disorder.

Design

A follow-up study of 25 AOS subjects and 25 age and sex-matched healthy subjects.

Outcome

Network theory will be applied to identify topological alterations in structural networks, including frontostriatal white matter (WM) tracts in relation to cognition and outcome measures.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
Workshop: brain changes in early onset psychosis
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S59
Copyright
Copyright © European Psychiatric Association 2017

References

James, A.Joyce, E.Lunn, D.Hough, M.Kenny, L.Ghataorhe, P., et al.Abnormal frontostriatal connectivity in adolescent-onset schizophrenia and its relationship to cognitive functioning. Eur Psychiatry 2016; 35: 32–3810.1016/j.eurpsy.2016.01.2426CrossRefGoogle ScholarPubMed
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