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First bipolar episode and functionality: Relation with depressive symptoms and inflammation levels

Published online by Cambridge University Press:  23 March 2020

M. Martinez-cengotitabengoa ,
C. Bermudez-ampudia ,
M.P. Lopez ,
A. Garcia-alocen ,
I. Gonzalez-ortega ,
I. Zorrilla  and
A. Gonzalez-pinto
M. Martinez-cengotitabengoa*
Affiliation:
CIBERSAM, University Hospital of Alava, National Distance Education University UNED, Psychiatry, Vitoria, Spain
C. Bermudez-ampudia
Affiliation:
CIBERSAM, University Hospital of Alava, Psychiatry, Vitoria, Spain
M.P. Lopez
Affiliation:
CIBERSAM, University Hospital of Alava, Psychiatry, Vitoria, Spain
A. Garcia-alocen
Affiliation:
CIBERSAM, University Hospital of Alava, Psychiatry, Vitoria, Spain
I. Gonzalez-ortega
Affiliation:
CIBERSAM, University Hospital of Alava, University of the Basque Country EHU-UPV, Psychiatry, Vitoria, Spain
I. Zorrilla
Affiliation:
CIBERSAM, University Hospital of Alava, Psychiatry, Vitoria, Spain
A. Gonzalez-pinto
Affiliation:
CIBERSAM- University Hospital of Alava, University of the Basque Country EHU-UPV, Psychiatry-Neurosciences, Vitoria, Spain
*
* Corresponding author.

Abstract

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Introduction

It is important to make an early and effective intervention from the first bipolar episode. The presence of depressive symptoms in the course of a manic episode could influence negatively the evolution and the prognosis of the patient. Inflammation and oxidative stress are also related with functionality.

Objectives

To explore the relationship between depressive symptoms during a first episode of mania, inflammatory parameters and patient functionality during the follow-up.

Method

We included in the study 92 are patients with a first manic episode and 92 matched healthy controls. We compared 13 inflammatory/oxidative stress parameters measured at baseline (TFNα, IL6, PGE2, MCP1, TBARS, NO2, SOD, CAT, GSHTOT, GSSG, GSHfree, GPx, TAS) between both groups. Between patients, 46 presented pure mania (PM) (no depressive symptoms) and 46 mixed mania (MM) (with depressive symptoms). We explored the influence of inflammatory factors in functionality, exploring differences between PM and MM. To measure patients’ general functioning one year after illness onset, we used the Functional Assessment Short Test (FAST).

Results

We found significant differences in TFNα, MCP1 and TBARS (higher in patients) and in SOD, GSHtot, GSSG, GSHfree, GPx and TAS levels (lower in patients). Only In MM group, there was a significant influence of SOD and GSHfree in FAST scores suggesting that a higher antioxidant levels at baseline the patient functionality improves one year after.

Conclusions

Some parameters of oxidative stress at baseline are related with patient's functionality one year after the first episode of mania, but only when mania debuts with depressive symptons simultaneously.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW36
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S122 - S123
Copyright
Copyright © European Psychiatric Association 2016
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