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Familial risk and prodromal features of psychosis in adolescents aged 15-16 years in the northern Finland 1986 birth cohort

Published online by Cambridge University Press:  16 April 2020

P.H. Maki
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland University Hospital of Oulu, Oulu, Finland Muurola Hospital, Hospital District of Lapland, Finland
J. Miettunen
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
A. Taanila
Affiliation:
Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
I. Moilanen
Affiliation:
University Hospital of Oulu, Oulu, Finland Clinic of Child Psychiatry, University of Oulu, Oulu, Finland
H. Ebeling
Affiliation:
University Hospital of Oulu, Oulu, Finland Clinic of Child Psychiatry, University of Oulu, Oulu, Finland
M. Joukamaa
Affiliation:
Tampere School of Public Health, University of Tampere, Tampere, Finland
E. Lauronen
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
M.R. Jarvelin
Affiliation:
Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, London, United Kingdom
P.B. Jones
Affiliation:
Departmento of Psychiatry, University of Cambridge, Cambridge, United Kingdom
G. Murray
Affiliation:
Departmento of Psychiatry, University of Cambridge, Cambridge, United Kingdom
M. Heinimaa
Affiliation:
Department of Psychiatry, University of Turku, Turku, Finland
J.M. Veijola
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland Academy of Finland, Helsinki, Finland

Abstract

Background and aims

Subjects with family history of psychosis and with prodromal symptoms are at risk for schizophrenia. The aim was to study whether adolescents with familial risk have more commonly prodromal features.

Methods

Members (N= 9,215) of the Northern Finland 1986 Birth Cohort, an unselected general population cohort, were invited to participate in a field survey conducted during 2001-2002. At the ages of 15-16 years, the study included a 21-item PROD-screen questionnaire developed for screening prodromal psychotic symptoms with 12 specific questions for psychosis (Heinimaa et al. 2003). The scale measured symptoms for last six months. The Finnish Hospital Discharge Register was used to find out parental psychoses during 1972-2000.

Results

Of the males 24% and 37% of the females were screen positives for prodromal features at the age of 15-16 years. Of the offspring, 1.8% had parents with psychosis. The prevalence of screen positives was 26% in males and 36% in females with familial risk for psychosis.

Conclusion

Prodromal features of psychosis are prevalent in adolescence. It may be difficult to screen adolescent subjects at risk for developing schizophrenia with a questionnaire in a general population, especially as these symptoms do not appear to be more common among subjects with familial risk.

Acknowledgements

The Academy of Finland, the National Institute of Mental Health, the Signe and Ane Gyllenberg Foundation and the Thule Institute, Finland.

Type
Unassigned abstracts
Copyright
Copyright © European Psychiatric Association 2007

References

Järvelin M-R et al. (1993); Br J Obst Gyn 100: 310-315CrossRefGoogle Scholar
Heinimaa M et al. (2003); Int J Methods Psychiatric Res 12(2): 92-104CrossRefGoogle Scholar
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