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Epigenetics in the Remission of Anorexia Nervosa: A Follow-up Study of Whole-genome Methylation Profiles

Published online by Cambridge University Press:  23 March 2020

N. Ramoz ,
S. Guillaume ,
P. Courtet  and
P. Gorwood
N. Ramoz
Affiliation:
Inserm U894, Center of Psychiatry and Neuroscience, Paris, France
S. Guillaume
Affiliation:
CHU de Montpellier, hôpital Lapeyronie–Psychiatry, Montpellier, France Inserm, U1061, Montpellier, France
P. Courtet
Affiliation:
CHU de Montpellier, hôpital Lapeyronie–Psychiatry, Montpellier, France Inserm, U1061, Montpellier, France
P. Gorwood
Affiliation:
Inserm U894, Center of Psychiatry and Neuroscience, Paris, France Hôpital Sainte-Anne, CMME, Paris, France

Abstract

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Introduction

Anorexia nervosa (AN) is a severe psychiatric disorder. The epigenetic regulations are strongly suggested in AN. We and other groups have performed a whole-genome methylation study (methylome) in AN. We found that the differentially methylated CpG sites are located around genes involved in biological processes in link with embryonic morphogenesis, brain development and its plasticity, in particular adhesion and axon guidance. Here, we study an independent group of 40 AN patients. Furthermore, we have done a follow-up during more than one year, to compare the methylation profiles in subjects that evolve to the remission.

Objectives

Our work is to replicate the methylome study in an independent AN cohort and to characterize profiles of methylation at two times for the same subjects to compare the AN patients that convert to remitters.

Aims

Our goal is to identify diagnostic and prognostic epigenetic signatures for AN.

Methods

Of the 40 AN patients, 18 evolved to remission. Furthermore, the blood samples of the subjects from the 2 times will be investigated, like this, each subject is its own control. Methylation of DNA is measured by using the Infinium HumanMethylation450 BeadChip technology.

Results

Comparisons of AN to controls showed similar profiles of methylation involving the same biological processes as previously identified. We are comparing now the difference of methylation between the 18 remitters and the 18 actual AN, taking into account of the two times of samples.

Conclusions

We expect to characterize specific methylation signature of the prognostic of the AN remission.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
Oral communications: Rehabilitation and psychoeducation and schizophrenia and other psychotic disorders
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S102
Copyright
Copyright © European Psychiatric Association 2017
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