Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-13T12:35:14.194Z Has data issue: false hasContentIssue false

Enhanced and Delayed Stress-induced Body Weight in Mice Lacking Functional Natriuretic Peptide-a Receptors

Published online by Cambridge University Press:  16 April 2020

J. Mutschler
Affiliation:
Department of Addictive Behavior and Addiction Medicine, Cetral Institute of Mental Health, University of Heidelberg, Mannheim, Germany
M. Grosshans
Affiliation:
Department of Addictive Behavior and Addiction Medicine, Cetral Institute of Mental Health, University of Heidelberg, Mannheim, Germany
H. Jahn
Affiliation:
Department of Psychiatry and Psychotherapie, University of Hamburg, Hamburg, Germany
K. Wiedemann
Affiliation:
Department of Psychiatry and Psychotherapie, University of Hamburg, Hamburg, Germany
R. Spanagel
Affiliation:
Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
F. Kiefer
Affiliation:
Department of Addictive Behavior and Addiction Medicine, Cetral Institute of Mental Health, University of Heidelberg, Mannheim, Germany

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Genetic and environmental influences are both known to be causal factors in the development and maintenance of obesity. Stress related chronic stimulation of the hypothalamic-pituitary-adrenal (HPA) axis and resulting increased glucocorticoid exposure is known to be an important pathophysiological mechanism in the development of obesity. We show that the natriuretic peptide system, that mediates endocrine and behavioural responses to stress, plays a role in the control of long-term body weight in chronically ethanol drinking mice. In mice lacking functional NPR-A receptors, physical, and in particular psychological stress leads to enhanced and continuous increase in body weight in homozygote NPR-A mice. The effect of repeated stress on body weight appeared rapidly and persisted throughout life. Over a longer period of time without stress, body weights do not differ between the different genotypes. Moreover, we could demonstrate that NPR-A homozygote mice show significant higher corticosterone levels following stress. Heterozygote animals show an intermediate phenotype concerning body weights and corticosterone levels following stress. Alterations in the NPR-A receptor gene may constitute a genetic risk factor for stress-induced eating and obesity.

Type
P03-258
Copyright
Copyright © European Psychiatric Association 2009
Submit a response

Comments

No Comments have been published for this article.