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The effects of prenatal morphine exposure on pain response

Published online by Cambridge University Press:  16 April 2020

M. Amini  and
A. Alijarahi
M. Amini
Affiliation:
Qazvin Azad University, Qazvin, Iran
A. Alijarahi
Affiliation:
Qazvin Azad University, Qazvin, Iran

Abstract

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Background

Drug abuse during pregnancy is a growing problem in all developed countries of the world. Maternal drug abuse affects the developing system and its long-term effects can persist till adulthood so it can decreases the rate of their maturation. Since endogenous opioid induced analgesia, and morphine can interact with it, Thus the present study was designed to determine whether the exposure to the morphine during gestation permanently alter pain response.

Objective

To determine the effects of prenatal morphine exposure on pain response

Materials and methods

12 Pregnant rats were divided to morphine and control groups.

Morphine was administrated (S.C) to female rats twice a day (08 h and 20 h) on gestational days 11–18, (5 mg/kg morphine for 3 days and 10 mg/kg for 5 days). Analgesic response of pups (P90, n = 6) were tested by formaline test.

Finding

The results of our experiment demonstrated that prenatal morphine exposure rats exhibited significantly lower pain thersholds.

Conclusion

Prenatal morphine exposure impair pain sensitivity

Type
P02-393
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 989
Copyright
Copyright © European Psychiatric Association 2011
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