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The effect of serotonin transporter gene promoter polymorphism on adolescent and adult ADHD symptoms and educational attainment: A longitudinal study

Published online by Cambridge University Press:  15 April 2020

E. Kiive  and
J. Harro
E. Kiive*
Affiliation:
Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, Tartu, 50410, Estonia
J. Harro
Affiliation:
Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, Tartu, 50410, Estonia
*
*Corresponding author. Tel.: +372 7 375 908; fax: +372 7 375 900. E-mail address:evelyn.kiive@ut.ee (E. Kiive).
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Abstract

Introduction:

The purpose of this longitudinal study was to investigate the relationship between the 5-HTTLPR genotype, symptoms of ADHD in adolescence and adulthood, and educational attainment in a population representative sample. Neuroticism, depressive symptoms and general mental abilities were controlled for as possible confounding factors.

Methods:

ADHD symptoms were reported at age 15 and 18 by teachers using the Hyperactivity Scale of af Klinteberg and SNAP-IV, and self-reported at age 25 using the ASRS. Data about education were reported at age 25.

Results:

At age 15, subjects with the l/l genotype had more concentration difficulties compared to s-allele carriers, and they also had more inattention symptoms according to SNAP-IV at age 18. These results were not altered by taking neuroticism or depressive symptoms into account. No 5-HTTLPR genotype effect on self-reported ADHD symptoms at age 25 was found. Inattention symptoms in adolescence were associated with lower education in young adulthood. The proportion of subjects with higher education at age 25 was significantly larger among s/s genotype compared to the l/l or s/l genotype.

Conclusions:

The l/l genotype of the 5-HTTLPR is associated with inattentive symptoms during adolescence in the general population, and increases the likelihood of inferior educational level in young adulthood.

Keywords

ADHD symptoms5-HTTLPREducationNeuroticismLongitudinal study
Type
Original article
Information
European Psychiatry , Volume 28 , Issue 6 , August 2013 , pp. 372 - 378
Copyright
Copyright © European Psychiatric Association

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References

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed, text rev. Washington, DC: American Psychiatric Association; 2000.Google Scholar
Barkley, RAMurphy, KRFischer, MADHD in adults: what the science says. New York: Guilford; 2008.Google Scholar
Barkley, RAKnouse, LEMurphy, KRCorrespondence and disparity in the self- and other ratings of current and childhood ADHD symptoms and impairment in adults with ADHD. Psychol Assess 2011;23:437–446.CrossRefGoogle ScholarPubMed
Belsky, JJonassaint, CPluess, MStanton, MBrummett, BWilliams, RVulnerability genes or plasticity genes?. Mol Psychiatry 2009;14:746–754.CrossRefGoogle ScholarPubMed
Biederman, JFaraone, SVAttention deficit hyperactivity disorder. Lancet 2005;36:237–248.CrossRefGoogle Scholar
Biederman, JFaraone, SVMick, EThe age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med 2006;36:159–165.CrossRefGoogle Scholar
Burnham, KEBaxter, MGBainton, JRSoutham, EDawson, LABannerman, DM, et al.Activation of 5-HT(6) receptors facilitates attentional set shifting. Psychopharmacology 2010;208:13–21.CrossRefGoogle ScholarPubMed
Calapoğlu, MSahin-Calapoğlu, NKaraçöp, ASoyöz, MElyıldırım, UYAvşaroğlu, SSerotonin transporter bi- and triallelic genotypes and their relationship with anxiety and academic performance: a preliminary study. Neuropsychobiology 2011;63:103–111.CrossRefGoogle ScholarPubMed
Coghill, DBanaschewski, TThe genetics of attention deficit/hyperactivity disorder. Expert Rev Neurother 2009;9:1547–1565.CrossRefGoogle ScholarPubMed
Curran, SPurcell, SCraig, IAsherson, PSham, PThe serotonin transporter gene as a QTL for ADHD. Am J Med Genet B Neuropsychiatr Genet 2005;134B:42–47.CrossRefGoogle ScholarPubMed
Depue, RASpoont, MRConceptualizing a serotonin trait. A behavioral dimension of constraint. Ann N Y Acad Sci 1986;487:47–62.CrossRefGoogle ScholarPubMed
DuPaul, GJWeyandt, LLO’Dell, SMVarejao, MCollege students with ADHD: current status and future directions. J Atten Disord 2009;13:234–250.CrossRefGoogle ScholarPubMed
Faraone, SVPerlis, RHDoyle, AESmoller, JWGoralnick, JJHolmgren, MA, et al.Molecular genetics of attention deficit/hyperactivity disorder. Biol Psychiat 2005;57:1313–1323.CrossRefGoogle ScholarPubMed
Frankle, WGHuang, YHwang, DRTalbot, PSSlifstein, MVan Heertum, R, et al.Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans. J Nucl Med 2004;45:682–694.Google ScholarPubMed
Frazier, TWYoungstrom, EAGlutting, JJWatkins, MWADHD and achievement: meta-analysis of the child, adolescent, and adult literatures and a concomitant study with college students. J Learn Disabil 2007;40:49–65.CrossRefGoogle Scholar
Gizer, IRFicks, CWaldman, IDCandidate gene studies of ADHD: a meta-analytic review. Hum Genet 2009;126:51–90.CrossRefGoogle ScholarPubMed
Harro, JMerenäkk, LNordquist, NKonstabel, KComasco, EOreland, LPersonality and the serotonin transporter gene: associations in a longitudinal population-based study. Biol Psychol 2009;81:9–13.CrossRefGoogle Scholar
Harro, MEensoo, DKiive, EMerenäkk, LAlep, JOreland, L, et al.Platelet monoamine oxidase in healthy 9- and 15-year-old children: the effect of gender, smoking and puberty. Prog Neuropsychopharmacol Biol Psychiat 2001;25:1497–1511.CrossRefGoogle Scholar
Homberg, JRLesch, KPLooking on the bright side of serotonin transporter gene variation. Biol Psychiatry 2011;69:513–519.CrossRefGoogle ScholarPubMed
Hu, XZLipsky, RHZhu, GAkhtar, LATaubman, JGreenberg, BD, et al.Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 2006;78:815–826.CrossRefGoogle ScholarPubMed
Kallasmaa, TAllik, JRealo, AMcCrae, RRThe Estonian version of the NEO-PI-R: an examination of universal and culture-specific aspects of the five-factor model. Eur J Pers 2000;14:265–278.3.0.CO;2-B>CrossRefGoogle Scholar
Kent, LDoerry, UHardy, EParmar, RGingell, KHawi, Z, et al.Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis. Mol Psychiatry 2002;7:908–912.CrossRefGoogle ScholarPubMed
Kessler, RCAdler, LAmes, MDemler, OFaraone, SHiripi, E, et al.The world health organization adult ADHD self-report scale (ASRS): a short screening scale for use in the general population. Psychol Med 2005;35:245–256.CrossRefGoogle Scholar
af Klinteberg, BStudies on sex-related psychological and biological indicators of psychosocial vulnerability: a developmental perspective. Stockholm: University of Stockholm, Department of Psychology; 1988.Google Scholar
af Klinteberg, BOreland, LHyperactive and aggressive behaviors in childhood as related to low platelet monoamine oxidase (MAO) activity at adult age: a longitudinal study of male subjects. Pers Individ Diff 1995;19:373–383.CrossRefGoogle Scholar
Laidra, KAllik, JHarro, MMerenäkk, LHarro, JAgreement among adolescents, parents and teachers on adolescent personality. Assessment 2006;13:187–196.CrossRefGoogle ScholarPubMed
Lesch, KPBengel, DHeils, ASabol, SZGreenberg, BDPetri, S, et al.Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527–1531.CrossRefGoogle ScholarPubMed
Loe, IMFeldman, HMAcademic and educational outcomes of children with ADHD. J Pediatr Psychol 2007;32:643–654.CrossRefGoogle ScholarPubMed
Lubke, GHHudziak, JJDerks, EMvan Bijsterveldt, TCBoomsma, DIMaternal ratings of attention problems in ADHD: evidence for the existence of a continuum. J Am Acad Child Psychiatry 2009;48:1085–1093.CrossRefGoogle ScholarPubMed
Lucki, IThe spectrum of behaviors influenced by serotonin. Biol Psychiatry 1998;4:151–162.CrossRefGoogle Scholar
Mannuzza, SKlein, RGBessler, AMalloy, PLaPadula, MAdult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status. Arch Gen Psychiatry 1993;50:565–576.CrossRefGoogle ScholarPubMed
Merenäkk, LMäestu, JNordquist, NParik, JOreland, LLoit, HM, et al.Effects of the serotonin transporter (5-HTTLPR) and α2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study. Psychopharmacology 2011;215:13–22.CrossRefGoogle ScholarPubMed
Montgomery, SAÅsberg, MA new depression scale designed to be sensitive to change. Br J Psychiatry 1979;134:382–389.CrossRefGoogle ScholarPubMed
Moffitt, TEBrammer, GLCaspi, AFawcett, JPRaleigh, MYuwiler, A, et al.Whole blood serotonin relates to violence in an epidemiological study. Biol Psychiatry 1998;43:446–457.CrossRefGoogle Scholar
Munafò, MRClark, TFlint, JDoes measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Mol Psychiatry 2005;10:415–419.CrossRefGoogle ScholarPubMed
Müller, DJMandelli, LSerretti, ADeYoung, CGDe Luca, VSicard, T, et al.Serotonin transporter gene and adverse life events in adult ADHD. Am J Med Genet B Neuropsychiatr Genet 2008;147B:1461–1469.CrossRefGoogle ScholarPubMed
Mõttus, RPullmann, HAllik, JTowards more readable big five personality inventories. Eur J Psychol Assess 2006;22:149–157.CrossRefGoogle Scholar
Polanczyk, Gde Lima, MSHorta, BLBiederman, JRhode, LAThe worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 2007;164:942–948.CrossRefGoogle ScholarPubMed
Polderman, TJDerks, EMHudziak, JJVerhulst, FCPosthuma, DBoomsma, DIAcross the continuum of attention skills: a twin study of the SWAN ADHD rating scale. J Child Psychol Psychiatry 2007;48:1080–1087.CrossRefGoogle ScholarPubMed
Polderman, TJBoomsma, DIBartels, MVerhulst, FCHuizink, ACA systematic review of prospective studies on attention problems and academic achievement. Acta Psychiatr Scand 2010;122:271–284.CrossRefGoogle ScholarPubMed
Raven, JRaven, JCCourt, JHManual for Raven's progressive matrices and vocabulary scales. Section 1: general overview San Antonio: Harcourt Assessment; 2003.Google Scholar
Retz, WFreitag, CMRetz-Junginger, PWenzler, DSchneider, MKissling, C, et al.A functional serotonin transporter promoter gene polymorphism increases ADHD symptoms in delinquents: interaction with adverse childhood environment. Psychiatry Res 2008;158:123–131.CrossRefGoogle ScholarPubMed
Ruotsalainen, SSirviö, JJäkälä, PPuumala, TMacDonald, ERiekkinen, PDifferential effects of three 5-HT receptor antagonists on the performance of rats in attentional and working memory tasks. Eur Neuropsychopharmacol 1997;7:99–108.CrossRefGoogle ScholarPubMed
Serretti, AMandelli, LLorenzi, CSmeraldi, ESocial adjustment could be associated with the serotonin transporter gene in remitted patients with mood disorders and healthy subjects. Psychiatry Res 2005;134:191–194.CrossRefGoogle ScholarPubMed
Simon, VCzobor, PBalint, SMeszaros, ABitter, IPrevalence and correlates of adult attention deficit hyperactivity disorder: meta-analysis. Br J Psychiatry 2009;194:204–211.CrossRefGoogle ScholarPubMed
Sobanski, EBrueggemann, DAlm, BKern, SPhilipsen, , Schmalzried, H, et al.Subtype differences in adults with attention deficit/hyperactivity disorder (ADHD) with regard to ADHD symptoms, psychiatric comorbidity and psychosocial adjustment. Eur Psychiatry 2008;23;142–149.CrossRefGoogle ScholarPubMed
Spencer, TBiederman, JWilens, TPharmacotherapy of attention deficit hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 2000;9:77–97.CrossRefGoogle ScholarPubMed
Spivak, BVered, YYoran-Hegesh, RAverbuch, EMester, RGraf, E, et al.Circulatory levels of catecholamines, serotonin and lipids in attention deficit hyperactivity disorder. Acta Psychiat Scand 1999;99:300–304.CrossRefGoogle ScholarPubMed
Swanson, JMKraemer, HCHinshaw, SPArnold, LEConners, CKAbikoff, HBClinical relevance of the primary findings of the MTA: Success rates based on severity of ADHD and ODD symptoms at the end of treatment. J Am Acad Child Psychiatry 2001;40:168–179.CrossRefGoogle ScholarPubMed
Thomason, MEHenry, MLPaul Hamilton, JJoormann, JPine, DSErnst, M, et al.Neural and behavioral responses to threatening emotion faces in children as a function of the short allele of the serotonin transporter gene. Biol Psychol 2010;85:38–44.CrossRefGoogle ScholarPubMed
Tomson, KMerenäkk, LLoit, HMMäestu, JHarro, JThe relationship between serotonin transporter gene promoter polymorphism and serum lipid levels at young age in a longitudinal population representative study. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:1857–1862.CrossRefGoogle Scholar
Wendland, JRMartin, BJKruse, MRLesch, KPMurphy, DLSimultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 2006;11:224–226.CrossRefGoogle ScholarPubMed
Weyandt, LLDuPaul, GADHD in college students. J Atten Disord 2006;10:9–19.CrossRefGoogle ScholarPubMed
Wittchen, HUJacobi, FRehm, JGustavsson, ASvensson, MJönsson, B, et al.The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 2011;21:655–679.CrossRefGoogle ScholarPubMed
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