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The effect of quetiapine monotherapy on subjective estimates of sleep in acute mania

Published online by Cambridge University Press:  16 April 2020

B.H. Yoon ,
W.M. Bahk ,
D.I. Jon ,
K.J. Min ,
A. Bae ,
Y.H. Sea  and
K.J. Kim
B.H. Yoon
Affiliation:
Department of Psychiatry, Naju National Hospital, Naju, Jeonnam, South Korea
W.M. Bahk
Affiliation:
Department of Psychiatry, School of Medicine, The Catholic University of Korea, Seoul, South Korea
D.I. Jon
Affiliation:
Department of Psychiatry, Hallym University, Sacred Heart Hospital, Anyang, South Korea
K.J. Min
Affiliation:
Department of Psychiatry, Chung-Ang University Hospital, Seoul, South Korea
A. Bae
Affiliation:
Department of Psychiatry, Naju National Hospital, Naju, Jeonnam, South Korea
Y.H. Sea
Affiliation:
Department of Psychiatry, Naju National Hospital, Naju, Jeonnam, South Korea
K.J. Kim
Affiliation:
Department of Psychiatry, Naju National Hospital, Naju, Jeonnam, South Korea Department of Psychiatry, College of Medicine, Sungkyun-Kwan University, Seoul, South Korea

Abstract

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Objective:

This study aimed to investigate the effect of quetiapine monotherapy on subjective feelings of sleep in patients with acute mania.

Method:

In a Korean multicenter, open-label, 6-week study, patients with a DSM-IV diagnosis of bipolar I disorder (manic or mixed episodes) were included to treatment with quetiapine (flexibly dosed up to 800mg/day). Clinical Improvement was evaluated using Young Mania Rating Scale (YMRS). Side effects were measured by Simpson-Angus Rating Scale (SARS) and Barnes Akathisia Rating Scale (BARS). Modified version of Leeds Sleep Evaluation Questionnaire (LSEQ) was used to assess the subjective measures of sleep, which included the factors covering four areas: i) getting to sleep (GTS), ii) quality of sleep (QOS), iii) awakening from sleep (AFS), and iv) behavior following wakefulness (BFW). All assessments were done at baseline and days 7, 14, 21 and 42 after treatment with quetiapine.

Results:

Fifty-six of 79 patients were completed the all assessments. Mean changes of YMRS from baseline were significant at days 7, 14, 21 and 42. There were no significant differences in SARS and BARS at any assessment. While mean changes of GTS, QOS and AFS from baseline were significantly improved at days 7, 14, 21 and 42, BFW was not differed between baseline and post-treatment assessments.

Conclusion:

Quetiapine monotherapy showed improvements of self-perceived sleep without any impairment following sleep in acute manic patients.

Type
Poster Session 2: Bipolar Disorders
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S263
Copyright
Copyright © European Psychiatric Association 2007
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