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Early-Onset Depression Is Associated With Specific Neurovegetative Symptoms

Published online by Cambridge University Press:  01 September 2022

E. Kasyanov ,
G. Rukavishnikov ,
A. Nikolishin ,
A. Gareeva ,
K. Savitskaya ,
A. Kazantseva ,
A. Kretsu ,
V. Soldatkin ,
T. Lezheyko  and
V. Golimbet
...Show all authors
E. Kasyanov*
Affiliation:
Bekhterev National Medical Center for Psychiatry and Neurology, Translational Psychiatry, Saint-Petersburg, Russian Federation
G. Rukavishnikov
Affiliation:
Bekhterev National Medical Center for Psychiatry and Neurology, Translational Psychiatry, Saint-Petersburg, Russian Federation
A. Nikolishin
Affiliation:
Federal State Budgetary Istitution Serbsky National Medical Research Centre for Psychiatry and Narcology of Ministry of Heath of the Russian Federation, Laboratory Of Molecular Genetics, Moscow, Russian Federation
A. Gareeva
Affiliation:
Institute of Biochemistry and Genetics of Ufa Federal Research Center of the Russian Academy of Sciences, Laboratory Of Human Molecular Genetics, Ufa, Russian Federation
K. Savitskaya
Affiliation:
Peoples’ Friendship University of Russia, Psychiatry, Moscow, Russian Federation
A. Kazantseva
Affiliation:
Laboratory of Human Molecular Genetics, Institute Of Biochemistry And Genetics, Ufa, Russian Federation
A. Kretsu
Affiliation:
Saint-Petersburg State University N.I.Pirogov Clinic of High Medical Technologies, Tharpy, Saint Petersburg, Russian Federation
V. Soldatkin
Affiliation:
Rostov State Medical University, Department Of Psychiatry, Addictology And Medical Psychology, Rostov-on-Don, Russian Federation
T. Lezheyko
Affiliation:
Mental Health Research Center, Clinical Genetics Laboratory, Moscow, Russian Federation
V. Golimbet
Affiliation:
Mental Health Research Center, Clinical Genetics Laboratory, Moscow, Russian Federation
N. Neznanov
Affiliation:
Bekhterev National Medical Center for Psychiatry and Neurology, Geriatric Psychiatry, Saint-Petersburg, Russian Federation
A. Kibitov
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Molecular Genetics Laboratory, Moscow, Russian Federation
G. Mazo
Affiliation:
Bekhterev National Medical Center for Psychiatry and Neurology, Translational Psychiatry, Saint-Petersburg, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

The age at onset of depression is not only an important clinical predictor of the further disease course, but also a robust marker, reflecting the genetic impact on depression risk.

Objectives

This study aimed to find whether early-onset depression had an association with specific clinical symptoms, comorbid psychiatric disorders and family history of mood disorders.

Methods

This pilot cross-sectional, multicenter study was performed under the supervision of the Russian National Consortium for Psychiatric Genetics. Early-onset depression was defined as the first depressive episode before the median age of onset in the sample (Me=29 years). Logistic regression models were used to determine the independent association of early-onset depression, after adjusting for the effects of sex and age, with binary characteristics.

Results

A total of 172 patients with depression were enrolled in the study (64.5% women; age - 40.9 (15.9) years). Early-onset depression was associated with psychomotor retardation (p=0,025; OR=2,3; 95%CI [1,1 - 4,9]), decreased libido (p=0,014; OR=2,8; 95%CI [1,2 - 6,2]), and lower prevalence of weight loss/decreased appetite (p=0,011; OR=0,4; 95%CI [0,2 - 0,8]). No associations were found with the history of comorbid psychiatric disorders and the family history of mood disorders.

Conclusions

Early-onset depression is associated with specific neurovegetative symptoms. Further clinical and genetic studies are needed to evaluate the specific effects of age at onset of depression on its clinical course.

Disclosure

Research is supported by an RSF grant №20-15-00132.

Keywords

DepressionFamily historyage at onsetNeurovegetative Symptoms
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S145 - S146
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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