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Early screening of autism spectrum disorder in general and pediatric practices, nurseries and early child care centers: Kitcat french study protocol using a two-stage procedure

Published online by Cambridge University Press:  13 August 2021

S. Marignier ,
N. Touil ,
F. Subtil ,
M. El Jani ,
S. Mardirossian ,
S. Gaillard ,
B. Kassai  and
S. Sonie
S. Marignier*
Affiliation:
Centre De Ressources Autisme Rhône Alpes, CH LE VINATIER, BRON, France
N. Touil
Affiliation:
Centre De Ressources Autisme Rhône Alpes, CH LE VINATIER, BRON, France
F. Subtil
Affiliation:
Pôle De Santé Publique, Service De Biostatistiques, HOSPICES CIVILS DE LYON, BRON, France
M. El Jani
Affiliation:
Epicime-cic 1407 De Lyon, HOSPICES CIVILS DE LYON, BRON, France
S. Mardirossian
Affiliation:
Centre De Ressources Autisme Rhône Alpes, CH LE VINATIER, BRON, France
S. Gaillard
Affiliation:
Epicime-cic 1407 De Lyon, HOSPICES CIVILS DE LYON, BRON, France
B. Kassai
Affiliation:
Epicime-cic 1407 De Lyon, HOSPICES CIVILS DE LYON, BRON, France
S. Sonie
Affiliation:
Centre De Ressources Autisme Rhône Alpes, CH LE VINATIER, BRON, France
*
*Corresponding author.

Abstract

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Introduction

Early screening of children at-risk to develop Autism Spectrum Disorder (ASD) needs to be improved to propose early interventions. This detection should allow diagnosis of ASD before the age of 3. An early screening performed at the general practitioner of the family should facilitate accessibility to diagnosis and a better collaboration between professionals.

Objectives

Our primary objective is to estimate the positive predictive value of an early detection kit composed of 2 questionnaires (First screening: M-CHAT-R/F™ + CSBS DP™-ITC) and a confirmation of the detection with a phone call by a neuropsychologist. Patients with confirmed positive M-CHAT-R/F™ and/or CSBS DP™-ITC scores are referred to a level 2 team for pre-diagnosis and diagnosis assessment.

Methods

The KitCAT study is a cohort study of 1,700 children aged 16 to 24 months seen in routine care in general or pediatric practices, or in nurseries and child care centers.

Results

Seven hundred and five children have already been enrolled in the study. Twenty nine patients, ie 4.1%, (with a confirmed positive M-CHAT-R/F™ and/or CSBS DP™-ITC scores) were referred to a level 2 team where a pre-diagnosis assessment was conducted by using the following test: ADI-R, ADOS 2, BLR, WPPSI-IV and Vineland II. The diagnosis of ASD (using the same test than the pre-diagnosis) was confirmed for the first two patients aged of 3.

Conclusions

The preliminary results confirm that the use of 2 questionnaires may optimize the reliability of the screening. A thousand children are still needed for the final analysis and further results are expected.

Disclosure

No significant relationships.

Keywords

questionnaires (M-CHAT-R/F™ + CSBS DP™-ITC)autism spectrum disorderearly screeningNeurodevelopmental disorders
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S155
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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