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The Dynamic Relationship of Olfaction and Emotion in Bipolar Disorders

Published online by Cambridge University Press:  15 April 2020

A.A. Dargél ,
E. Siopi ,
G. Gheusi ,
F. Isel ,
P.M. Lledo  and
C. Henry
A.A. Dargél
Affiliation:
Eq15 Psychiatrie Génétic Fondation FondaMental, INSERM U955, Créteil, France
E. Siopi
Affiliation:
Department of Neurosciences-Laboratory for Perception and Memory, Institut Pasteur, Paris, France
G. Gheusi
Affiliation:
Department of Neurosciences-Laboratory for Perception and Memory, Institut Pasteur, Paris, France
F. Isel
Affiliation:
EA 7326, Institut of Psychology Sorbonne Paris Cité, Paris, France
P.M. Lledo
Affiliation:
Department of Neurosciences-Laboratory for Perception and Memory, Institut Pasteur, Paris, France
C. Henry
Affiliation:
Eq15 Psychiatrie Génétique, INSERM U955, Créteil, France

Abstract

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Olfactory dysfunction has been correlated with alterations in the emotional processes in several neuropsychiatric disorders. However, there is little research on olfactory processing and emotional regulation in bipolar disorder. We aim to explore the potential relationship between these two relevant dimensions (olfaction and emotional response) in patients with bipolar disorders.

Methods

Olfactory perception and emotional reactivity were assessed by the Multidimensional Assessment of Thymic State (MATHYS) in a large sample of stable bipolar patients (N = 1,271).

Preliminary Results

We observed a significant negative correlation between olfactory perception and subsyndromal depressive symptoms (r=-0.8; P < 0.01) while a slight positive correlation between olfactory perception and manic symptoms was found (r=0.2; P < 0.01). Limitations: The degree of olfactory perception was assessed by self-report questionnaire.

Conclusion

Odor perception may be an illness state marker of mood syndromes in bipolar disorder. Alternatively, differences in odor perception may identify heterogeneous subgroups within the bipolar spectrum. Further studies are needed to understand the implications of odor perception as well as other signatures (e.g. deficit in odor acuity, deficits in the affective processing related to olfaction) in patients with bipolar disorder.

Type
Article: 0460
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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