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Do bipolar II and bipolar I disorder have different genotypes and why do we observe unipolar depression converting to bipolar II and then bipolar I?

Published online by Cambridge University Press:  23 March 2020

M. Agius ,
M. Fawcett  and
R. Zaman
M. Agius*
Affiliation:
University of Cambridge, Psychiatry, Cambridge, United Kingdom
M. Fawcett
Affiliation:
University of Cambridge, School of Clinical Medicine, Cambridge, United Kingdom
R. Zaman
Affiliation:
University of Cambridge, Psychiatry, Cambridge, United Kingdom
*
* Corresponding author.

Abstract

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We review the recent literature in order to establish the importance of a spectrum for bipolar affective disorder, and that unipolar depression, bipolar II and bipolar I are discrete entities that may however evolve in sequence. We discuss clinical, genetic and neurobiological data which illustrate the differences between bipolar I and bipolar II. To fit the data we suggest a series of multiple mood disorder genotypes, some of which evolve into other conditions on the bipolar spectrum. Thence, we discuss the nature of the bipolar spectrum and demonstrate how this concept can be used as the basis of a staging model for bipolar disorder.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV151
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S328
Copyright
Copyright © European Psychiatric Association 2016
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