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Depression and the Risk of Autoimmune Disease: a Prospective Study On a Nationwide Representative Sample

Published online by Cambridge University Press:  15 April 2020

N. Andersson ,
L.N. Gustafsson ,
N. Okkels ,
F. Tara ,
S.W. Cole ,
P. Munk-Jϕrgensen  and
R.D. Goodwin
N. Andersson
Affiliation:
Department M, Aarhus University Hospital, Risskov, Denmark
L.N. Gustafsson
Affiliation:
Department M, Aarhus University Hospital, Risskov, Denmark
N. Okkels
Affiliation:
Department M, Aarhus University Hospital, Risskov, Denmark
F. Tara
Affiliation:
Department of Psychology, Queens College and The Graduate Center. City University of New York (CUNY), New York, USA
S.W. Cole
Affiliation:
Division of Hematology-Oncology Department of Medicine, UCLA. School of Medicine, Los Angeles, USA
P. Munk-Jϕrgensen
Affiliation:
Department M, Aarhus University Hospital, Risskov, Denmark
R.D. Goodwin
Affiliation:
Department of Epidemiology, Mailman School of Public Health. Columbia University, New York, USA

Abstract

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Background

Depression is associated with various inflammatory-related physical conditions, such cardiovascular and neurodegenerative diseases. Yet, little is known about the association between depression and autoimmune diseases.

Objectives and Aims

To examine the association between depression and risk of autoimmune disease, investigating the temporal and dose-response nature of these relationships.

Methods

A prospective study including approximately 1.1 million people is conducted using linked Danish registries. We have identified 145,217 participants with depression between 1995 and 2012. Survival analyses are used to estimate the relative risk of autoimmune disease among those with, compared to without, depression. Analyses are adjusted for covariates.

Results

Preliminary analyses indicate an association between depression and an increased risk of several autoimmune diseases, with a potential dose-response correlation. Final results are still in progress.

Conclusion

Depression seems to be associated with increased risk of the onset of a range of autoimmune diseases. As such, depression may play a role in the etiology of certain autoimmune conditions.

Type
Article: 0339
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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