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Dehydroepiandrosterone sulfate (DEHA-S), cortisol and adrenocorticotropic hormone (ACTH) levels in drug-naive, first episode patients with psychosis

Published online by Cambridge University Press:  13 August 2021

P. Petrikis ,
S. Tigas ,
M. Christou ,
S. Brikos ,
A. Karampas ,
G. Georgiou  and
T. Hyphantis
P. Petrikis
Affiliation:
Department Of Psychiatry, UNIVERSITY OF IOANNINA-FACULTY OF MEDICINE, IOANNINA, Greece
S. Tigas
Affiliation:
Department Of Endocrinology, UNIVERSITY OF IOANNINA-FACULTY OF MEDICINE, IOANNINA, Greece
M. Christou
Affiliation:
Department Of Endocrinology, UNIVERSITY OF IOANNINA-FACULTY OF MEDICINE, IOANNINA, Greece
S. Brikos
Affiliation:
Department Of Psychiatry, UNIVERSITY OF IOANNINA-FACULTY OF MEDICINE, IOANNINA, Greece
A. Karampas*
Affiliation:
Department Of Psychiatry, UNIVERSITY OF IOANNINA-FACULTY OF MEDICINE, IOANNINA, Greece
G. Georgiou
Affiliation:
Department Of Psychiatry, UNIVERSITY OF IOANNINA-FACULTY OF MEDICINE, IOANNINA, Greece
T. Hyphantis
Affiliation:
Department Of Psychiatry, UNIVERSITY OF IOANNINA-FACULTY OF MEDICINE, IOANNINA, Greece
*
*Corresponding author.

Abstract

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Introduction

Impaired response to stress and a pathological activation of the hypothalamic-pituitary-adrenal axis have been implicated in the pathophysiology of schizophrenia

Objectives

To measure serum ACTH, cortisol and DEHA-S levels in drug-naïve, first-episode patients with psychosis.

Methods

Results are reported as mean (standard deviation, range). Paired t-test or Wilcoxon signed rank test were performed for group comparisons. The level of significance was set at p-value<0.05. Statistical analysis was performed with Stata 15.1.

Results

Data were included for 110 subjects (70 men, 40 women); 55 patients and 55 controls matched for age and sex. Mean age was 31.3 years (8.7, 18-48) in patients and 31.4 years (8.9, 17-49) in controls. Serum cortisol and Cortisol/DHEA-S ratio were statistically significantly lower in patients [12.6μg/dl (4.5, 3.5-24.5) and 5.3 (3.6, 1.3-19.5), respectively] compared to controls [15.5 μg/dl (4.9, 4.2-30.1) and 8 (4.7, 1.1-25.5), respectively] (p-value=0.0068 and 0.0005, respectively). Additionally, serum DHEA-S was statistically significantly higher in patients [306.5 μg/dl(165.4, 70-790)] compared to controls [240.1 μg/dl(113.5, 46-597)] (p-value=0.0114). ACTH was also higher in patients [28.5 pg/ml(15.7, 6.2-73.9)] than controls [26.5 pg/ml (15.3, 7-70.5)] but this difference wasn’t statistically significant (p-value=0.6359).

Conclusions

We report elevated DEHA-S, decreased cortisol levels and decreased cortisol/DEHA-S ratio in the patients’ compared to the controls’ group.

Disclosure

No significant relationships.

Keywords

DEHA-SACTHpsychosiscortisol
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S808 - S809
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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