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The Danish OPUS-trial: RCT of standard treatment versus integrated treatment in first episode psychosis. 5 years follow-up

Published online by Cambridge University Press:  16 April 2020

M. Nordentoft ,
M. Bertelsen ,
A. Thorup ,
L. Petersen ,
J. Ahlenschleger ,
T. Christensen ,
G. Krarup ,
P. LeQuack  and
P. Jorgensen
M. Nordentoft
Affiliation:
Department of Psychiatry, Bispebjerg Hospital, Copenhagen University, Copenhagen, Denmark
M. Bertelsen
Affiliation:
Department of Psychiatry, Bispebjerg Hospital, Copenhagen University, Copenhagen, Denmark
A. Thorup
Affiliation:
Department of Psychiatry, Bispebjerg Hospital, Copenhagen University, Copenhagen, Denmark
L. Petersen
Affiliation:
Department of Psychiatry, Bispebjerg Hospital, Copenhagen University, Copenhagen, Denmark
J. Ahlenschleger
Affiliation:
SCT Hans Hospital, Roskilde, Denmark
T. Christensen
Affiliation:
Psychiatric Hospital, Risskov, Aarhus, Denmark
G. Krarup
Affiliation:
Psychiatric Hospital, Risskov, Aarhus, Denmark
P. LeQuack
Affiliation:
Psychiatric Hospital, Risskov, Aarhus, Denmark
P. Jorgensen
Affiliation:
Psychiatric Hospital, Risskov, Aarhus, Denmark

Abstract

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Aim

To evaluate the effects of integrated treatment for first-episode psychotic patients.

Method

In a randomised clinical trial of 547 first-episode patients with schizophrenia spectrum disorders, effects of integrated treatment and standard treatment was compared. The integrated treatment lasted for two years and consisted of assertive community treatment with programmes for family-involvement and social skills training. Standard treatment offered contact with a community mental health centre. Patients were assessed at entry and after one, two and five years by investigators that were not involved in treatment.

Results

At the one-year and two-year follow-up psychotic and negative symptoms changed in favour of integrated treatment. Patients in integrated treatment had significantly less co-morbid substance abuse, better adherence to treatment, and more satisfaction with treatment. Use of bed days was 22 percent less in integrated treatment than in standard treatment. Results of five-year follow-up will be presented.

Conclusion

Integrated treatment improved clinical outcome and adherence to treatment. The improvement in clinical outcome was consistent in the one-year and two-year follow-ups.

Type
Unassigned abstracts
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S84
Copyright
Copyright © European Psychiatric Association 2007
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