EMDR therapy is a new approach to psychotherapy that uses alternating bilateral stimulation, either through the movement of the eyes or through auditory or cutaneous stimuli, to induce rapid resolution of symptoms related to past events. The protocol of EMDR therapy is based on a set of principles that are essential to a humanistic and integrative approach to medicine and health: confidence in the self-healing capacity of each individual, the importance of history personal approach, a person-centered approach, restored power, the importance of mind-body bonding, well-being and performance improvement. Several controlled studies have demonstrated the remarkable effectiveness of EMDR therapy for post-traumatic stress disorder resolution. Indeed, to date, EMDR therapy is one of the best documented methods of treating post-traumatic stress disorder in the scientific literature. We report here the clinical case of a young lady with post-traumatic stress disorder complicated by depressive disorder, on borderline personality, and as comorbidity a polyaddition to tobacco, alcohol and cannabis, and in whom EMDR therapy proved its efficacy in the management of her disease, enabling her to return to a better life.