Hostname: page-component-848d4c4894-v5vhk Total loading time: 0 Render date: 2024-06-19T15:43:03.316Z Has data issue: false hasContentIssue false
  • English
  • Français

Clonidine test and MMPI scales in major depression: state or trait markers ?

Published online by Cambridge University Press:  16 April 2020

M Hansenne ,
W Pitchot ,
A Gonzalez Moreno ,
R von Frenckell  and
M Ansseau
M Hansenne
Affiliation:
Psychiatric Unit, Centre Hospitalier Universitaire du Sart-Tilman, B 35, B-4000Liège, Belgium
W Pitchot
Affiliation:
Psychiatric Unit, Centre Hospitalier Universitaire du Sart-Tilman, B 35, B-4000Liège, Belgium
A Gonzalez Moreno
Affiliation:
Psychiatric Unit, Centre Hospitalier Universitaire du Sart-Tilman, B 35, B-4000Liège, Belgium
R von Frenckell
Affiliation:
Psychiatric Unit, Centre Hospitalier Universitaire du Sart-Tilman, B 35, B-4000Liège, Belgium
M Ansseau
Affiliation:
Psychiatric Unit, Centre Hospitalier Universitaire du Sart-Tilman, B 35, B-4000Liège, Belgium
Get access

Summary

The relationship between growth hormone (GH) response to clonidine and the Minnesota Multiphasic Personality Inventory (MMPI) was assessed in 20 major depressive inpatients. GH response to clonidine was negatively correlated with the depression, the psychasthenia as well as the social introversion MMPI scale scores, and positively correlated with the hypomania scale scores. In contrast, the Carroll depression scale did not exhibit any relationship with either GH response to clonidine or MMPI depression scale. These findings support the role of the clonidine test and several MMPI scales as trait markers for depressive illness.

Keywords

MMPIclonidine testmajor depressionCarroll depression scale
Type
Original article
Information
European Psychiatry , Volume 7 , Issue 3 , 1992 , pp. 129 - 133
Copyright
Copyright © Elsevier, Paris 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Agren, H (1982) Depressive symptom patterns and urinary MHPG excretion Psychiatry Res 6, 185–196CrossRefGoogle ScholarPubMed
Ansseau, MScheyvaerts, MDoumont, APoirrier, RLegros, J-JFranck, G (1984) Concurrent use of REM latency, dexamethasone suppression, clonidine, and apomorphine tests as biological markers of endogenous depression : a pilot study Psychiatry Res 12, 261–272CrossRefGoogle ScholarPubMed
Ansseau, Mvon Frenckell, RFranck, GGeenen, VLegros, J-J (1986) Dexamethasone suppression test and MMPI scales Neuropsychobiology 16, 68–71CrossRefGoogle ScholarPubMed
Ansseau, Mvon Frenckell, RCerfontaine, J-LPapart, PFranck, GTimsit-Berthier, MGeenen, VLegros, J-J (1987) Neuroendocrine evaluation of catecholaminergic neurotransmission in mania Psychiatry Res 22, 193–206CrossRefGoogle ScholarPubMed
Ansseau, Mvon Frenckell, RCerfontaine, J-LPapart, PFranck, GTimsit-Berthier, MGeenen, VLegros, JJ (1988) Blunted response of growth hormone to clonidine and apomorphine in endogenous depression Br J Psychiatry 153, 65–71CrossRefGoogle ScholarPubMed
Ansseau, MLamberty, Cvon Frenckell, RPapart, PGérard, M-AWauthy, JFranck, G (1990) Life-events and biological markers of depression. In: Psychiatry: a World Perspective (Stefanis, CNSoldatos, CRRabavilas, AD, eds) Excerpta Medica, Amsterdam, 265–269Google Scholar
Beckman, HGoodwin, FK (1980) Urinary MHPG in subgroups of depressed patients and normal controls Neuropsychobiology 6, 91–100CrossRefGoogle Scholar
Bryer, JBBorrelli, DJMatthews, EJKornetsky, C (1983) The psychological correlates of the DST in depressed patients Psychopharmacol Bull 19, 633–637Google Scholar
Carroll, BJFeinberg, MSmouse, PERawson, SGGreden, JF (1981) The Carroll rating scale for depression. I. Development, reliability and validation Br J Psychiatry 138, 194–200CrossRefGoogle Scholar
Charney, DSHeninger, GRSternberg, DEHafstad, KMGiddings, SLandis, DH (1982) Adrenergic receptor sensitivity in depression: effects of clonidine in depressed patients and healthy subjects Arch Gen Psychiatry 39, 290–294CrossRefGoogle ScholarPubMed
Checkley, SASlade, APShur, E (1981) Growth hormone and other responses to clonidine in patients with endogenous depression Br J Psychiatry 138, 51–55CrossRefGoogle ScholarPubMed
Franchimont, P (1968) Le dosage radio-immunologique de I’hormone de croissance humaine Cah Méd Lyon 44, 887–898Google Scholar
Graham, JR (1987) The MMPI. A practical guide 2nd edn. Oxford University Press, New YorkGoogle Scholar
Hillhouse, EWBurden, JJones, MT (1975) The effects of various putative neurotransmitters on the release of corticotrophin releasing hormone from the hypothalamus of the rat in vitro: the effect of acetylcholine and noradrenaline Neuroendocrinology 17, 1–11CrossRefGoogle ScholarPubMed
Lewi, PJPinchard, AG (1967) An automated Minnesota multiphasic personality inventory test Acta Psychologica 27, 397–399CrossRefGoogle Scholar
Matussek, NAckenheil, MHippius, HMuller, FTSchroder, FSchultes, HWasilewski, B (1980) Effect of clonidine on growth hormone release in psychiatric patients and controls Psychiatry Res 2, 25–36CrossRefGoogle ScholarPubMed
Mitchell, PBBeam, JACorn, THCheckley, SA (1988) Growth hormone response to clonidine after recovery in patients with endogenous depression Br J Psychiatry 152, 34–38CrossRefGoogle ScholarPubMed
Norman, WHKeitner, GIMiller, IW (1985) MMPI, personality dysfunction and the dexamethasone suppression test in major depression J Affect Disord 9, 97–101CrossRefGoogle ScholarPubMed
Pitchot, WHansenne, MGonzalez Moreno, Avon Frenckell, RAnsseau, M (1990-91) Psychopathological correlates of dopaminergic disturbances in major depression Neuropsychobiology 24, 169–172CrossRefGoogle Scholar
Post, RM (1980) Biochemical theories of mania. In: Mania: an Evolving Concept (Belmaker, RHvan Praag, HM, eds) Spectrum Publications, New York, 175–215Google Scholar
Post, RMBallenger, JCJimerson, DCGold, PWGoodwin, FKRubinow, DRBunney, WE (1981) Cerebrospinal fluid amines and peptides in affective illness. In: Recent Advances in Neuropsychopharmacology (Angrist, BBurrows, GDLader, MLingjaerde, OSedvall, GWheatley, D, eds) Pergamon, New York, 275–282CrossRefGoogle Scholar
Siever, LJUhde, TWSilberman, EKJimerson, DCAloi, JAPost, RMMurphy, DL (1982) Growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls Psychiatry Res 6, 171–183CrossRefGoogle ScholarPubMed
Siever, LJUhde, TW (1984) New studies and perspectives on the noradrenergic receptor system in depression: effects of the alpha-2 adrenergic agonist clonidine Biol Psychiatry 19, 131–156Google ScholarPubMed
Stokes, PStoll, PMattson, MSollod, R (1976) Diagnosis and psychopathology in psychiatric patients resistant to dexamethasone. In: Hormones, Behavior, and Psychopathology (Sachar, EJ, ed) Raven Press, New York, 225–229Google Scholar
Szadoczky, ERihmer, ZArato, MFazekas, IAbonyi, E (1983) Adatok az un neurotikus depressziok heterogenitasahoz. A klinikai es neuroendokrinologiai elkulonites Iehetosegei Ideggyogyaszati Szemie 36, 461–467Google Scholar
Tulandi, TLal, SGuyda, H (1987) Effect of estrogen on the growth hormone response to the alpha-adrenergic agonist clonidine in women with menopausal flushing J Clin Endocrinol Metab 65, 6–10CrossRefGoogle ScholarPubMed
Willner, P (1985) Depression: a Psychobiological Synthesis. Wiley, New YorkGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.