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Clinical and biological features associated to bipolar disorder with comorbid migraine: results from the FACE-BD cohort

Published online by Cambridge University Press:  19 July 2023

M.-C. Patoz ,
O. Godin ,
X. Moisset ,
J. Chabert ,
K. M’Bailara ,
B. Etain ,
R. Belzeaux ,
C. Dubertret ,
E. Haffen  and
R. Schwan
...Show all authors
M.-C. Patoz*
Affiliation:
CHU Clermont-Ferrand, Université Clermont Auvergne, Institut Pascal, clermont ferrand
O. Godin
Affiliation:
fondation fondamental, créteil
X. Moisset
Affiliation:
Université Clermont Auvergne, CHU de Clermont-Ferrand, Inserm, Neuro-Dol, clermont ferrand
J. Chabert
Affiliation:
CHU Clermont-Ferrand, Université Clermont Auvergne, Institut Pascal, clermont ferrand
K. M’Bailara
Affiliation:
fondation fondamental, créteil LabPsy, University of Bordeaux, EA 4139 Department of Clinical and Academic Psychiatry, Charles-Perrens Hospital, Bordeaux
B. Etain
Affiliation:
fondation fondamental, créteil AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Fernand Widal INSERM UMRS 1144-Université de Paris, Paris
R. Belzeaux
Affiliation:
fondation fondamental, créteil Pôle de Psychiatrie, Assistance Publique Hôpitaux de Marseille INT-UMR 7289, CNRS Aix-Marseille Université, Marseille
C. Dubertret
Affiliation:
fondation fondamental, créteil Department of Psychiatry, University of Paris, AP-HP, Louis Mourier Hospital, INSERM UMR 1266 PARIS, Colombes
E. Haffen
Affiliation:
fondation fondamental, créteil Service de Psychiatrie de l’Adulte, CIC-1431 INSERM, CHU de Besançon, Laboratoire de Neurosciences, Université de Franche-Comté, UBFC, Besançon
R. Schwan
Affiliation:
fondation fondamental, créteil Université de Lorraine, Centre Psychothérapique de Nancy, Pôle Hospitalo-Universitaire de Psychiatrie d’Adultes du Grand Nancy, INSERM U1254, Nancy
P. Roux
Affiliation:
fondation fondamental, créteil Centre Hospitalier de Versailles, Le Chesnay, EA 4047 HANDIReSP, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin-en-Yvelines, Versailles, France and Université Paris-Saclay, UVSQ, Inserm, CESP, Equipe “PsyDev”, Villejuif
M. Polosan
Affiliation:
fondation fondamental, créteil Université Grenoble Alpes, Inserm U1216, Grenoble Institut de Neurosciences, CHU de Grenoble, Grenoble
V. Aubin
Affiliation:
fondation fondamental, créteil Pôle de Psychiatrie, Centre Hospitalier Princesse Grace, Monaco
M. Leboyer
Affiliation:
fondation fondamental, créteil Université Paris Est Creteil (UPEC), AP-HP, Hôpitaux Universitaires «H. Mondor», DMU IMPACT, INSERM, IMRB, Translational Neuropsychiatry, Créteil
P. Courtet
Affiliation:
fondation fondamental, créteil Institute of Functional Genomics, University of Montpellier, CNRS, INSERM Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, Montpellier
E. Olie
Affiliation:
fondation fondamental, créteil Institute of Functional Genomics, University of Montpellier, CNRS, INSERM Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, Montpellier
P.-M. Llorca
Affiliation:
fondation fondamental, créteil CHU Clermont-Ferrand, Université Clermont Auvergne, Institut Pascal, Clermont-Ferrand, France
L. Samalin
Affiliation:
fondation fondamental, créteil CHU Clermont-Ferrand, Université Clermont Auvergne, Institut Pascal, Clermont-Ferrand, France
*
*Corresponding author.

Abstract

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Introduction

Migraine and bipolar disorder (BD) are two chronic and recurrent disorders with a major impact on patient’s quality of life. It is now well known that affective disorders and migraine are often comorbid (Leo et al. Scand J Pain. 2016; 11:136-145). Starting from these observations, we can hypothesis that BD patients with comorbid migraine might have specifical clinical and biological features.

Objectives

The aim of this study was to estimate the prevalence of migraine in a cohort of French BD patients; determine sociodemographic, clinical, and biological features associated BD-migraine comorbidity.

Methods

4348 BD patients from the FACE-BD cohort were included from 2009 to 2022. Sociodemographic and clinical characteristics, lifestyle information, and data on antipsychotic treatment and comorbidities were collected, and a blood sample was drawn. The Structured Clinical Interview for DSM-IV Axis I Disorders was used to confirm the diagnosis of BD. Migraine diagnosis was established according to a clinician-assessed questionnaire.

Results

20.1% of individuals with BD had comorbid migraine. Half of these patients received treatment for migraine. Multivariate logistic regression model showed that risk of migraine in women was nearly twice that in men (OR = 1.758; 95% CI, 1.345-2.298). Anxiety disorder, sleep disturbances and childhood trauma were also associated with an increased risk of migraine comorbidity. Patients receiving antipsychotic treatment had less risk of developing migraine than those not receiving those treatment (OR 0.716, 95% CI, 0.554-0.925), independent of other potential confounders.

Conclusions

The prevalence of migraine in our cohort was lower than those previously reported in other studies. This result might suggest an overestimation of migraine diagnosis in BD patients population studies. However, BD-migraine comorbidity could constitute a subphenotype of bipolar disorder requiring specific treatments.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S388
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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