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Body mass index and depressive rumination are positively associated with each other only in case of GG genotype of catenin alpha 2 gene rs13412541 variant

Published online by Cambridge University Press:  01 September 2022

N. Eszlari ,
Z. Bagyura ,
A. Millinghoffer ,
T. Nagy ,
G. Juhasz ,
P. Antal ,
B. Merkely  and
G. Bagdy
N. Eszlari*
Affiliation:
Semmelweis University, Department Of Pharmacodynamics, Budapest, Hungary
Z. Bagyura
Affiliation:
Semmelweis University, Heart And Vascular Center, Budapest, Hungary
A. Millinghoffer
Affiliation:
Budapest University of Technology and Economics, Department Of Measurement And Information Systems, Budapest, Hungary
T. Nagy
Affiliation:
Budapest University of Technology and Economics, Department Of Measurement And Information Systems, Budapest, Hungary
G. Juhasz
Affiliation:
Semmelweis University, Department Of Pharmacodynamics, Budapest, Hungary
P. Antal
Affiliation:
Budapest University of Technology and Economics, Department Of Measurement And Information Systems, Budapest, Hungary
B. Merkely
Affiliation:
Semmelweis University, Heart And Vascular Center, Budapest, Hungary
G. Bagdy
Affiliation:
Semmelweis University, Department Of Pharmacodynamics, Budapest, Hungary
*
*Corresponding author.

Abstract

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Introduction

Catenin alpha 2 gene (CTNNA2) is important in the stability of hippocampal synapses and also in brain development. Our recent paper (Eszlari et al, Pharmaceuticals 2021, 14, 850) has demonstrated that rumination on sad mood mediates the association of CTNNA2 only towards psychiatric symptoms, but not towards cardiovascular risk phenotypes.

Objectives

Our present aim was to test the moderating role of rumination and its two subtypes, brooding and reflection, in genetic associations between CTNNA2 and the same cardiovascular risk phenotypes.

Methods

633 unrelated subjects from the Budakalasz Health Examination Survey with non-missing phenotypic data, and 160 single-nucleotide CTNNA2 variants remaining after quality control, were included. Linear regression models were run in Plink 1.9 for separate outcomes of body mass index (BMI), and Framingham risk scores for cardiovascular disease, coronary heart disease, myocardial infarction, and stroke. With each variant, predictors were the variant, rumination or its subtype, the variant x rumination interaction, sex, age, and the top ten principal components of the genome. 100,000 label-swapping max(T) permutation was applied for the interaction term within each analysis.

Results

While no significant interaction term survived the familywise permutation, two trends emerged. Namely, BMI seems to have positive association with rumination and its maladaptive brooding subtype only in case of GG genotype of rs13412541, otherwise no association can be detected.

Conclusions

Although replication is needed in larger samples, the relationship between rumination and BMI, conditional on CTNNA2 genotype, can be important in atypical depression, thus may contribute to stratification of depressed patients.

Disclosure

The study was supported by the New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (ÚNKP-21-4-II-SE-1); and by 2019-2.1.7-ERA-NET-2020-00005.

Keywords

perseverative negative thinkingbody mass indexcatenin alpha 2depressive rumination
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S228 - S229
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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