Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-12-03T15:55:21.800Z Has data issue: false hasContentIssue false

Biomarkers and clinical predictors of long-term course in obsessivecompulsive disorder: A prospective cohort study

Published online by Cambridge University Press:  19 July 2023

S. López-Rodriguez*
Affiliation:
1Obsessive-Compulsive Disorder (OCD) Division, Psychiatry Department, Bellvitge University Hospital, Barcelona
P. Alonso Ortega
Affiliation:
1Obsessive-Compulsive Disorder (OCD) Division, Psychiatry Department, Bellvitge University Hospital, Barcelona
C. Segalàs Cosi
Affiliation:
1Obsessive-Compulsive Disorder (OCD) Division, Psychiatry Department, Bellvitge University Hospital, Barcelona
E. Real Barrero
Affiliation:
1Obsessive-Compulsive Disorder (OCD) Division, Psychiatry Department, Bellvitge University Hospital, Barcelona
S. Bertolín Triquell
Affiliation:
1Obsessive-Compulsive Disorder (OCD) Division, Psychiatry Department, Bellvitge University Hospital, Barcelona
C. Soriano Mas
Affiliation:
1Obsessive-Compulsive Disorder (OCD) Division, Psychiatry Department, Bellvitge University Hospital, Barcelona
Á. Carracedo Alvarez
Affiliation:
2Medicina Legal y Forense, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
J. M. Menchón Magriña
Affiliation:
1Obsessive-Compulsive Disorder (OCD) Division, Psychiatry Department, Bellvitge University Hospital, Barcelona
*
*Corresponding author.

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction

The purpose of the research project is to analyze the long-term evolution of obsessive-compulsive disorder (OCD) from of a study of a cohort of patients prospectively followed over a period ranging from 5 to 20 years, treated for according to therapeutic guidelines mediating serotonin reuptake inhibitors (IRS) and drug enhancers (antipsychotics) and cognitive behavioral therapy and evaluated in a standardized manner.

Objectives

To assess the long-term course of Obsessive-Compulsive Disorder (OCD) in a cohort of patients treated according to current clinical guidelines; to analyse possible prognostic factors associated with the long-term course of the disorder including clinical and sociodemographic variables, as well as genetic and neuroimaging biomarkers, and their interaction, and finally to study neuroanatomical and functional cerebral connectivity changes after 15 years of treatment in a subsample of patients.

Methods

Prospective, descriptive, and observational study of a cohort of OCD patients, receiving treatment at the Department of Psychiatry of Hospital de Bellvitge since 1998, according to a standardized protocol. Follow-up period ranges from 5 (n=423), to 10 (n= 247) and 15 years (123). Baseline clinical and sociodemographic assessment, long-term evolution and information on treatments provided are available for the whole sample. Data on whole exome sequencing is available for 300 of the patients included in the cohort and baseline structural neuroimaging and cerebral functional connectivity has been analysed in 168 subjects. To expand the analysis of genetic biomarkers, we propose the study of de novo variants through exome analysis of 50 trios (patient and both parents) selected among those subjects that have reached 15 years of follow-up (25 trios with patients within the “long-term remission” group and 25 trios with patients with chronic OCD). De novo variants detected in the trio analysis will be replicated in the rest of the sample. A structural and resting state MRI will be obtained in a subsample of 100 patients recruited among those who have completed a minimum follow-up period of 15 years, to assess cerebral changes associated with the long-term course of the disorder.

Results

in the current moment the recruitment period of the study has ended and all the data is being statistically analysed in order to provide solid results in a short period of time.

Conclusions

The identification of those factors associated with an increased risk of chronic disease is an element essential to offer personalized treatment to our patients and improve their prognosis, emphasizing the intensive use of those therapeutic strategies for which we can predict a better response and modifying to the extent of, if possible, environmental factors or factors of access to treatment that contribute to perpetuate obsessive symptoms.

Disclosure of Interest

None Declared

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
Submit a response

Comments

No Comments have been published for this article.