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Biological profile of medical response in alcoholic patients of different ethnic groups in Siberia

Published online by Cambridge University Press:  13 August 2021

T. Shushpanova ,
T. Novozheeva ,
N. Bokhan ,
M. Belousov ,
E. Bezverkhnyaya ,
N. Kolomiets  and
A. Mandel
T. Shushpanova*
Affiliation:
Clinical Psychoneuroimmunology And Neurobiology Lab, Mental Health Research Institute, Tomsk, Russian Federation
T. Novozheeva
Affiliation:
Clinical Psychoneuroimmunology And Neurobiology Lab, Mental Health Research Institute, Tomsk, Russian Federation Neurobiology, Mental Health Research Institute Tomsk National Research Medical Center Russia Academy of Science, Tomsk, Russian Federation
N. Bokhan
Affiliation:
The Department Of Addictive States, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation
M. Belousov
Affiliation:
Department Of Pharmaceutical Analysis, Siberian State Medical University, Tomsk, Russian Federation
E. Bezverkhnyaya
Affiliation:
Institute Of Physics Of High Technologies, Tomsk Polytechnic University, Tomsk, Russian Federation
N. Kolomiets
Affiliation:
Department Of Pharmaceutical Analysis, Siberian State Medical University, Tomsk, Russian Federation
A. Mandel
Affiliation:
The Department Of Addictive States, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

The individual sensitivity of a person to the effects of alcohol is defined as the possibility of adaptive reactions, which are controlled by various factors associated in their manifestation with characteristics in various ethnic populations.

Objectives

To determine biological profile of medical response in alcoholic patients of different ethnic groups.

Methods

168 alcoholic men, aged 17 to 62 years were examined. For the therapeutic correction of withdrawal and post-withdrawal symptoms of patients from two different ethnic groups (Tatars and Russians in Siberia), the original anticonvulsant galodif (M-chloro-benzhydrylurea) was used. Pharmacokinetic parameters were calculated a model-independent method of statistical moments: half-life (T1/2,h), total clearance (Clt,ml/min), average time of the residual drug in the body (MRI,h), average elimination time (MET,h), the area under the pharmacokinetic curve (AUC, μg/ml).

Results

Galodif causes a reduction in almost half T1/2, a significant decrease in the average time of the residual drug in the body MRI, and the average elimination time MET. Overall clearance increased. Under the influence of the course with Galodif, antipyrine elimination intensified, which indicates the induction of the cytochrome P-450 system of microsomal liver monooxygenases in Russian alcoholic patients. Galodif causes a reduction of almost five-fold T1/2, a significant decrease MRI and MET. Activation of oxidative metabolism of xenobiotics in Tatar alcoholic patients is more significant.

Conclusions

The increased sensitivity of P-450 cytochrome system to anticonvulsants action with inductive detoxification properties reflects differences in adaptive mechanisms in human from various ethnic groups, what is significant in the therapy.

Disclosure

No significant relationships.

Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S685
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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