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Biological determinants of functioning in euthymic patients with Bipolar Disorder: A multicentric 3-year cohort study

Published online by Cambridge University Press:  01 September 2022

Y. Cañada*
Affiliation:
La Fe University and Polytechnic Hospital, Psychiatry, Valencia, Spain La Fe Health Research Insitute, Mental Health Research Group, Valencia, Spain
A. García-Blanco
Affiliation:
La Fe University and Polytechnic Hospital, Psychiatry, Valencia, Spain La Fe Health Research Institute, Neonatal Research Group, Valencia, Spain
P. Navalón
Affiliation:
La Fe University and Polytechnic Hospital, Psychiatry, Valencia, Spain La Fe Health Research Institute, Neonatal Research Group, Valencia, Spain
M. Sanchez Autet
Affiliation:
Parc Sanitari San Joan de Deu, Psychiatry, Barcelona, Spain
L. De La Fuente Tomas
Affiliation:
University of Oviedo, Department Of Psychiatry, Oviedo, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain
M.P. Garcia-Portilla
Affiliation:
Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain University of Oviedo, Department Of Psychiatry, oviedo, Spain
B. Arranz
Affiliation:
Parc Sanitari San Joan de Deu, Psychiatry, Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain
P. Sierra San Miguel
Affiliation:
La Fe University and Polytechnic Hospital, Psychiatry, Valencia, Spain La Fe Health Research Insitute, Mental Health Research Group, Valencia, Spain
*
*Corresponding author.

Abstract

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Introduction

Bipolar disorder is related with functional impairment in euthymia. The contribution of biological functions such as sleep, sexual functioning; or the presence of obesity on this loss remain understudied.

Objectives

The aim of this work was to study the influence of biological determinants in context with clinical and demographical determinants of functioning in a 3-year cohort of euthymic BD patients.

Methods

In this multicentric study 67 euthymic adult bipolar outpatients were followed during three years. Functioning was assessed with FAST, insomnia severity with Oviedo Sleep Questionnaire (OSQ) and, sexual functioning with Changes on Sexual Functioning Questionnaire (CSFQ-14) and obesity was expressed as body mass index (BMI). The basal effect of sleep, sexual functioning and obesity (Time 0) on FAST (Time 3) was analyzed with a mixed ordinal regression model including time effect, age, sex, number of manic and depressive episodes, euthymia length, and comorbidity with personality disorder. Change in functioning (Time 3 to 0) was analyzed in another mixed model also considering the difference in biological determinants (Time 3 to 0) and the presence of mood episodes during the period.

Results

A basal worse sexual functioning, a higher severity of insomnia and a higher BMI predicted a worse functioning at three years (p=0.005, p=0.043, p=0.05 respectively). Regarding FAST difference from Time0 to 3, only having a manic episode related to an impairment on functioning (p=0.027).

Conclusions

Sexual functioning, quality of sleep and BMI are predictors of functioning in euthymia in BD. Manic episodes in the following contribute to impairments on functioning more than depressive episodes.

Disclosure

No significant relationships.

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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