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Attention-deficit/hyperactivity disorder endophenotypes - an overview

Published online by Cambridge University Press:  16 April 2020

T. Banaschewski*
Affiliation:
Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Mannheim, Germany

Abstract

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Attention-deficit/hyperactivity disorder (ADHD) is a clinically heterogeneous, highly heritable and genetically complex disorder. The pathways from genes to behaviour are still unknown. Endophenotypes, or intermediate phenotypes that are more closely linked to the neurobiological substrate than the core symptoms of ADHD, may help to disentangle these complex relationships between genes and behaviour and to clarify its etiology and pathophysiology. Heritability and stability represent key components of any useful endophenotype. Various other criteria for the selection of useful endophenotypes have been proposed. A review of the current state of the research on potential endophenotypes for ADHD will be given.

Type
S41. Symposium: Genes, Endophenotypes and Treatment of Adult ADHD
Copyright
Copyright © European Psychiatric Association 2007
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