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Association study of catechol-O-methyltransferase Val158Met polymorphism with personality traits in japanese healthy volunteers

Published online by Cambridge University Press:  30 August 2007

Genki ishii ,
Akihito Suzuki ,
Shingo Oshino ,
Hiroaki Shiraishi ,
Yoshihiko Matsumoto ,
Koichi Otani  and
Kaoru Goto
Genki ishii
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
Akihito Suzuki*
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
Shingo Oshino
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
Hiroaki Shiraishi
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
Yoshihiko Matsumoto
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
Koichi Otani
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
Kaoru Goto
Affiliation:
Department of anatomy and Cell Biology, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata990-9585, Japan
*
∗Corresponding author. Tel.: +81 23 628 5322; fax: +81 23 628 5325. E-mail address: suzukiakihito@hotmail.com (A. Suzuki).
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Abstract

Catechol-O-methyltransferase (COMT) is one of the major enzymes for the degradation of catecholamines. It has been suggested that catecholaminergic neurotransmission is involved in characterization of personality. Previous studies on the association between the COMT Val158Met polymorphism and personality traits in healthy subjects have produced inconsistent results. Therefore, the relationship between this polymorphism and personality was re-examined in 478 Japanese healthy volunteers. Personality traits were assessed by the Temperament and Character inventory (TCI), and the COMT genotypes were determined by a PCR-RFLP method. in total, there were no significant differences among the Val/Val, Val/Met, and Met/Met genotypes in seven TCI dimension scores. Similarly, no significant relationship was found between the COMT genotypes and the TCI dimensions when males and females were analyzed separately. The present study thus suggests that the COMT Val158Met polymorphism is not associated with personality traits in Japanese healthy subjects.

Keywords

Catechol-O-methyltransferase Val158Met polymorphismHealthy subjectsPersonalityTemperament and Character inventory
Type
Original article
Information
European Psychiatry , Volume 22 , Issue 7 , October 2007 , pp. 462 - 465
Copyright
Copyright © Elsevier Masson SAS 2007

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References

Akil, M., Kolachana, B.S., Rothmond, D.A., Hyde, T.M., Weinberger, D.R., Kleinman, J.E.Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. J Neurosci 2003;23:2008–2013.CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed.Washington, DC: American Psychiatric Association; 1994.Google Scholar
Barnett, J.H., Jones, P.B., Robbins, T.W., Muller, U.Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Mol Psychiatry 2007;12:502–509.CrossRefGoogle ScholarPubMed
Chen, J., Lipska, B.K., Halim, N., Ma, Q.D., Matsumoto, M., Melhem, S.et al.Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 2004;75:807–821.CrossRefGoogle ScholarPubMed
Cloninger, C.R., Przybeck, T.R., Svrakic, D.M.The Tridimensional Personality Questionnaire: US normative data. Psychol Rep 1991;69:1047–1057.CrossRefGoogle Scholar
Cloninger, C.R., Svrakic, D.M., Przybeck, T.R.A psychobiological model of temperament and character. Arch Gen Psychiatry 1993;50:975–990.CrossRefGoogle ScholarPubMed
Cooper, J.R., Bloom, F.E., Roth, R.H.The biochemical basis of neuropharmacology. 8th ed.Oxford, UK: Oxford University Press; 2003.Google Scholar
Gogos, J.A., Morgan, M., Luine, V., Santha, M., Ogawa, S., Pfaff, D.et al.Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci USA 1998;95:9991–9996.CrossRefGoogle ScholarPubMed
Grossman, M.H., Emanuel, B.S., Budaf, M.L.Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1–q11.2. Genomics 1992;12:822–825.CrossRefGoogle Scholar
Kijima, N., Saito, R., Suzuki, M., Yoshino, A., ono, Y., Kato, M.et al.Cloninger's seven factor model of temperament and character and Japanese version of Temperament and Character inventory (TCI). Jpn J Psychiatr Diagn 1996;7:379–399 (Japanese).Google Scholar
Kim, S.J., Kim, Y.S., Kim, S.Y., Lee, H.S., Kim, C.H.an association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans. Neurosci Lett 2006;401:154–158.CrossRefGoogle ScholarPubMed
Krabbendam, L., isusi, P., Galdos, P., Echevarria, E., Bilbao, J.R., Martin-Pagola, A.et al.Associations between COMTVal158Met polymorphism and cognition: direct or indirect effect? Eur Psychiatry 2006;21:338–342.CrossRefGoogle ScholarPubMed
Lachman, H.M., Papolos, D.F., Saito, T., Yu, Y.M., Szumlanski, C.L., Weinshilboum, R.M.Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996;6:243–250.CrossRefGoogle ScholarPubMed
Meyer-Lindenberg, A., Kohn, P.D., Kolachana, B., Kippenhan, S., Mcinerney-Leo, A., Nussbaum, R.et al.Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Nat Neurosci 2005;8:594–596.CrossRefGoogle ScholarPubMed
Reuter, M., Hennig, J.Association of the functional catechol-O-methyltransferase VAL158MET polymorphism with the personality trait of extraversion. NeuroReport 2005;16:1135–1138.CrossRefGoogle ScholarPubMed
Suzuki, A., Fukasawa, T., Shiraishi, H., ishii, G., Oshino, S., Aoshima, T.et al.No association between the TPH A218C polymorphism and personality traits in Japanese healthy subjects. Prog Neuropsychopharmacol Biol Psychiatry 2007;31:395–398.CrossRefGoogle ScholarPubMed
Tsai, S.J., Hong, C.J., Yu, Y.W., Chen, T.J.Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young Chinese females. Neuropsychobiology 2004;50:153–156.CrossRefGoogle ScholarPubMed
Wu, R.M., Cheng, C.W., Chen, K.H., Lu, S.L., Shan, D.E., Ho, Y.F.et al.The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese. Neurology 2001;56:375–382.CrossRefGoogle ScholarPubMed
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