Hostname: page-component-594f858ff7-jtv8x Total loading time: 0 Render date: 2023-06-05T11:25:59.572Z Has data issue: false Feature Flags: { "corePageComponentGetUserInfoFromSharedSession": false, "coreDisableEcommerce": false, "corePageComponentUseShareaholicInsteadOfAddThis": true, "coreDisableSocialShare": false, "useRatesEcommerce": true } hasContentIssue false

Association of loneliness and social network size in adulthood with childhood maltreatment: Analyses of a population-based and a clinical sample

Published online by Cambridge University Press:  05 September 2022

Matthias A. Reinhard*
Department of Psychiatry and Psychotherapy, LMU University Hospital Munich, Munich, Germany
Stephanie V. Rek
Department of Psychiatry and Psychotherapy, LMU University Hospital Munich, Munich, Germany International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany
Tabea Nenov-Matt
Department of Psychiatry and Psychotherapy, LMU University Hospital Munich, Munich, Germany
Barbara B. Barton
Department of Psychiatry and Psychotherapy, LMU University Hospital Munich, Munich, Germany
Julia Dewald-Kaufmann
Department of Psychiatry and Psychotherapy, LMU University Hospital Munich, Munich, Germany
Katharina Merz
Department of Psychiatry and Psychotherapy, LMU University Hospital Munich, Munich, Germany
Richard Musil
Department of Psychiatry and Psychotherapy, LMU University Hospital Munich, Munich, Germany
Andrea Jobst
Department of Psychiatry and Psychotherapy, LMU University Hospital Munich, Munich, Germany
Eva-Lotta Brakemeier
Department of Clinical Psychology and Psychotherapy, University of Greifswald, Greifswald, Germany
Katja Bertsch
Department of Psychology, Ludwig-Maximilians-University Munich, Munich, Germany
Frank Padberg
Department of Psychiatry and Psychotherapy, LMU University Hospital Munich, Munich, Germany
*Author for correspondence: Matthias A. Reinhard, E-mail:



Perceived loneliness and objective social network size are related but distinct factors, which negatively affect mental health and are prevalent in patients who have experienced childhood maltreatment (CM), for example, patients with persistent depressive disorder (PDD) and borderline personality disorder (BPD). This cross-diagnostic study investigated whether loneliness, social network size, or both are associated with self-reported CM.


Loneliness and social network size were assessed in a population-based sample at two time points (Study 1, N = 509), and a clinical group of patients with PDD or BPD (Study 2, N = 190) using the UCLA Loneliness Scale and the Social Network Index. Further measures were the Childhood Trauma Questionnaire, and standard depression rating scales. Linear regression analyses were applied to compare associations of loneliness or social network size with CM. Multiple mediation analyses were used to test the relative importance of loneliness and social network size in the relationship between CM and depressive symptoms.


In both studies, loneliness showed a stronger association than social network size with CM. This was particularly marked for emotional neglect and emotional abuse. Loneliness but not social network size mediated the relationship between CM and depressive symptoms.


Loneliness is particularly associated with self-reported CM, and in this respect distinct from the social network size. Our results underline the importance of differentiating both psychosocial constructs and suggest focusing on perceived loneliness and its etiological underpinnings by mechanism-based psychosocial interventions.

Research Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (, which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association


Loneliness is a pervasive and adverse experience that is strongly linked to the perception of social isolation [Reference Hawkley and Cacioppo1]. Both persistent loneliness and social isolation may have deleterious consequences for physical and mental health [Reference Heinrich and Gullone2Reference Qualter, Vanhalst, Harris, Van Roekel, Lodder and Bangee4], and represent risk factors for the development and maintenance of psychiatric conditions, such as depression [Reference Hawkley and Cacioppo1, Reference Domenech-Abella, Lara, Rubio-Valera, Olaya, Moneta and Rico-Uribe5Reference van Winkel, Wichers, Collip, Jacobs, Derom and Thiery7]. A deeper understanding of the etiological and maintaining factors of loneliness and social isolation remains an important research endeavor with the ultimate aim to optimize prevention and treatment efforts. This may allow to reduce the burden of loneliness and its negative consequences on mental health.

It is helpful to clearly define the entities of loneliness and social isolation in order to validly study these related, yet distinct phenomena [Reference Quadt, Esposito, Critchley and Garfinkel8]: Loneliness is an aversive feeling resulting from the perceived mismatch between existing relationship and subjective social needs [Reference Peplau and Perlman9]. In contrast, social isolation is an objective criterion that describes a reduced number or absence of social relationships, that is, a small social network size [Reference Cornwell and Waite10]. A small social network is neither a necessary nor sufficient condition to elicit feelings of loneliness as also illustrated by only weak to moderate correlations between the two constructs [Reference Cornwell and Waite10, Reference Coyle and Dugan11]. An individual may even experience self-sufficiency and immersion into a pleasurable flow when being alone (so-called solitude [Reference Jacobs12]). Therefore, loneliness may result from a specific perception and subjective evaluation of one’s own social network (i.e., “perceived social isolation” [Reference Cacioppo and Hawkley13]) that does not sufficiently “serve to meet basic emotional needs” [Reference Quadt, Esposito, Critchley and Garfinkel8] (p. 283). In this context, it appears promising to investigate where this perception of unsatisfying social relationships stems from.

Possible influential factors for loneliness and social isolation are adverse prior experiences in life. A history of childhood maltreatment (CM) may hinder individuals to establish close relationships with others [Reference Negriff, James and Trickett14, Reference Sperry and Widom15] and to build social networks [Reference McLafferty, O’Neill, Armour, Murphy and Bunting16]. Individuals with a history of CM may develop negative expectations that caregivers and others are not available and untrustworthy [Reference Cicchetti, Toth, Lamb and Lerner17] possibly resulting in increased social fear and avoidance [Reference Muller, Bertsch, Bulau, Herpertz and Buchheim18]. In addition, CM is associated with increased rejection sensitivity [Reference Nenov-Matt, Barton, Dewald-Kaufmann, Goerigk, Rek and Zentz19]. This anxious expectation of being rejected may lead to social withdrawal and hostility that actually elicits rejection by others resulting in a self-fulfilling prophecy [Reference Romero-Canyas, Downey, Berenson, Ayduk and Kang20, Reference Downey and Feldman21]. Finally, an association between CM and difficulties in emotion regulation may further negatively affect social relationships [Reference Heleniak, Jenness, Stoep, McCauley and McLaughlin22]. Indeed, existing studies on this topic found an association of CM with loneliness later in life in clinical samples with different psychiatric disorders (e.g., borderline personality disorder [BPD], persistent depressive disorder [PDD], late-life depression, drug addiction, psychotic disorder) and non-clinical samples [Reference Nenov-Matt, Barton, Dewald-Kaufmann, Goerigk, Rek and Zentz19, Reference Merz and Jak23Reference Lin and Chiao29]. These studies suggest that a history of CM may increase the risk to experience loneliness and/or social isolation later in life. However, a clear distinction between these two constructs is missing in the context of CM research.

CM also represents a major risk factor for chronicity and psychopathology, that is, depressive syndromes [Reference Danese and Widom30, Reference Li, D’Arcy and Meng31], yet the mechanisms and pathways underlying this relationship are not fully understood [Reference McLaughlin, Colich, Rodman and Weissman32]. Interestingly, loneliness and social isolation precede depression when assessed longitudinally [Reference van Winkel, Wichers, Collip, Jacobs, Derom and Thiery7], and therefore may mediate the path from CM to depressive symptoms as has been found for patients with late-life depression [Reference Wielaard, Hoyer, Rhebergen, Stek and Comijs28].

Thus, our main hypothesis here was that CM is positively associated with loneliness and/or negatively with the social network size. For this purpose, we conducted secondary analyses in two studies with (a) a population-based sample and (b) a clinical sample consisting of patients with BPD or PDD particularly characterized by high rates of CM, loneliness, and a small social network size to test the robustness and generalizability of our findings. On an explorative level, the strengths of the associations of different forms of CM with loneliness versus social network size, and the relative importance of loneliness and social network size as potential mediators in the relationship between CM and depressive psychopathology were analyzed across both samples.



Both studies followed the Declaration of Helsinki and were approved by the Institutional Review Board (IRB) of the Ludwig Maximilians University, Faculty of Medicine, Munich (Study 1: IRB No. 20–118; Study 2: IRB-Nos. 281–11 and 713–15). Participants gave their written informed consent prior to participation. Studies were preregistered on Open Science Forum (OSF; for IRB No. 20–118: OSF.IO/3EVN9) and at the German Clinical Trials Register (DRKS, for IRB No. 713–15: DRKS00019821).

Study 1

Data were derived from N = 509 population-based participants who were part of an ongoing longitudinal survey into the mental health consequences of the coronavirus disease-2019 (COVID-19) pandemic [Reference Rek, Buhner, Reinhard, Freeman, Keeser and Adorjan33]. Participants were recruited from the general population via social media advertisements and university mailing lists. The inclusion criteria of the study included a minimum age of 18. The prospective online survey assessed psychopathological symptoms, social network characteristics, and loneliness, in addition to other questionnaires at two time points [Reference Rek, Buhner, Reinhard, Freeman, Keeser and Adorjan33]. Of the 509 individuals at baseline, 345 participated in a 10 week follow-up assessment. No significant differences were observed between participants that dropped out and participants that provided data at two time points in terms of sociodemographic characteristics and reported measures (see Table 1). The secure online “LimeSurvey” software with a forced response format and questionnaire block randomization was used in this study. As a compensation for their participation, participants were given the opportunity to win gift vouchers.

Table 1. Baseline characteristics of the population-based sample (Study 1) stratified by follow-up participation.

Study 2

A clinical sample was derived from 190 psychiatric inpatients (94 patients with BPD and 96 patients with PDD) who participated in two trials at the Department of Psychiatry and Psychotherapy of the LMU University Hospital, Munich, Germany. Patients were mainly recruited from two wards that specialized in the treatment of patients with BPD and PDD, respectively [Reference Barton, Goerigk, Wustenberg, Dewald-Kaufmann, Reinhard and Musil34, Reference Reinhard, Padberg, Dewald-Kaufmann, Wustenberg, Goerigk and Barton35]. Diagnoses were assessed with the German version of the Structured Clinical Interview for DSM-IV (SCID-I/-II) or The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) (SCID-5-CV/-PD) by trained and supervised psychologists or psychiatrists. As the German version of the DSM-5 was already available before the release of SCID-5-CV, PDD diagnosis was additionally confirmed with DSM-5 criteria.



The UCLA Loneliness Scale [Reference Russell, Peplau and Cutrona36] (German version: [Reference Döring and Bortz37]) consists of 20 items that measure the frequency and intensity of loneliness. Items are rated on a 5-point Likert scale ranging from 1 (not at all) to 5 (totally). After recoding reversed items, items are averaged to form a mean score. The internal consistency for the German version is high (Cronbach α = 0.89 [Reference Döring and Bortz37]).

Social network size

The Social Network Index (SNI [Reference Cohen, Doyle, Skoner, Rabin and Gwaltney38]) assesses how many people the respondent meets or talks to at least once every 2 weeks within 12 different domains of social relationships (e.g., parents, friends). The 12 items range from 0 to “7 or more” persons. The number of persons per domain is summarized as a total network size score. This score was used as a dimensional indicator for the extent of social isolation with a smaller network size indicating more social isolation.

Childhood maltreatment

The Childhood Trauma Questionnaire (CTQ [Reference Bernstein and Fink39], German version: [Reference Wingenfeld, Spitzer, Mensebach, Grabe, Hill and Gast40]), consists of 25 items that measure the subjective experiences of emotional, physical and sexual abuse as well as emotional and physical neglect before the age of 18 years. Items are rated on a 5-point Likert scale ranging from 1 (never true) to 5 (very often true). Subscales range from 5 to 25. For the CTQ total score subscales were summed up. Internal consistency of all subscales is high apart from physical neglect (Cronbach α > 0.80 [Reference Klinitzke, Romppel, Hauser, Brahler and Glaesmer41]).

Depressive symptoms

The population-based sample filled out the Depression, Anxiety and Stress Scale-21 (DASS-21 [Reference Lovibond and Lovibond42], German version [Reference Nilges and Essau43]) 10 weeks after measuring loneliness and social network size. In the following, the depression subscale was used, which shows a high internal consistency (Cronbach α > 0.90 [Reference Nilges and Essau43]). For patients, we used the Beck Depression Inventory (BDI-II [Reference Beck, Steer, Ball and Ranieri44], German version: [Reference Hautzinger, Keller and Kühner45]) as DASS-21 scores were not available in this sample. BDI-II was measured cross-sectionally and shows a high internal consistency (Cronbach α > 0.84 [Reference Kuhner, Burger, Keller and Hautzinger46]). The correlation between the depression subscale of the DASS-21 and BDI-II was found to be strong in a German sample (r = 0.68 [Reference Nilges and Essau43]).

Statistical analyses

Statistical analyses were conducted with R v4.0.3 [47]. There were no missing data at baseline in Study 1. In Study 2, two patients had missing data and were excluded from the specific analyses concerning the social network size. Analyses were performed independently yet identically for the two studies due to different sample sizes and characteristics, sampling methods, and questionnaires. Descriptive statistics are presented in mean and standard deviation. To test our main hypothesis, regression analyses were performed with total CTQ as an independent variable and either loneliness or social network size as a dependent variable. Variables were standardized to ease the interpretation of results. Results were controlled for age and sex. Fisher’s Z was computed to compare the strength of correlation coefficients for loneliness versus social network size. In addition, regression analyses were separately repeated for each CTQ subscale as an independent variable. p-values were adjusted according to [Reference Benjamini and Hochberg48]. Finally, multiple mediation analyses were performed to test whether loneliness and smaller social network size mediated the relationship between total CTQ and depressive symptoms. Mediating variables were allowed to correlate in these models.


Study 1

Data of 509 participants from the general population (78.2% female, mean age: 30.1 ± 11.1 years) were analyzed. Participants reported a mean score of 2.2 ± 0.8 on the UCLA loneliness scale and an average social network size of 14.8 ± 8.8 people. Loneliness correlated negatively with the social network size (r = −0.41, p < 0.001). Participants reported an average total CTQ of 37.4 ± 12.9. According to [Reference Bernstein and Fink39], the average reported emotional abuse was low to moderate (mean: 9.0 ± 4.6) as was emotional neglect (mean: 9.9 ± 4.7). The sample reported none to minimal physical neglect (mean: 6.9 ± 2.6), physical abuse (mean: 5.9 ± 2.1), and sexual abuse (mean: 5.7 ± 2.6). The mean DASS-21 depression score was 12.1 ± 10.6, indicating a significant prevalence of depressive symptoms [Reference Nilges and Essau43].

Higher loneliness and a smaller social network size were found to be significantly associated with the total CTQ score (see Figure 1 and Table 2). The correlation between loneliness with total CTQ was stronger than of social network size with total CTQ when comparing the strengths of the regression coefficients (Z = 5.7, p < 0.001). Furthermore, loneliness and social network size were significantly associated with all CTQ subscales (despite physical abuse). The strongest associations were found for the subscales of emotional neglect and emotional abuse with loneliness.

Figure 1. Association of loneliness and smaller social network size with childhood trauma questionnaire (CTQ) in a population-based (non-clinical) and a clinical sample.

Table 2. Regression analyses for loneliness and social network size as dependent variables and childhood trauma questionnaire (CTQ) total score and subscales as predictors in the population-based (Study 1) and clinical sample (Study 2).

Note: Outcome and predictor variables were standardized to ease interpretation of results. Age and sex (standardized) were included as covariates.

* p < 0.05;

** p < 0.01;

*** p < 0.001 significance level after Benjamini–Hochberg p-value correction.

Finally, multiple mediation analyses were performed including depressive symptoms in the population-based sample (see Figure 2 and Table 3). Here, loneliness—but not social network size—fully mediated the relationship between CTQ and depressive symptoms at 10-week follow-up.

Figure 2. Mediation model of childhood maltreatment (CM) as predictor of depression mediated by loneliness and social network size in Study 1 (A) and Study 2 (B).

Table 3. Results of multiple mediation analyses with childhood maltreatment as predictor of depression and loneliness and social network size as mediators.

Note: Depicted are total, total indirect, and direct effects of the different multiple mediation models.

Abbreviations: CI, confidence interval (bootstrapped); DV, dependent variable; Std., standardized.

Study 2

The clinical sample consisted of 190 psychiatric patients (65.3% female, mean age: 33.3 ± 12.3 years, n = 96 patients with BPD, n = 94 patients with PDD). Patients reported a mean loneliness level of 2.9 ± 0.8 and a social network size of 9.4 ± 6.4 people. Patients’ loneliness correlated significantly negatively with social network size (r = −0.30, p < 0.001). Total CTQ was 55.2 ± 17.5. CTQ subscales of the clinical sample ranged from moderate to severe emotional abuse (mean: 14.8 ± 5.7) and emotional neglect (mean: 15.9 ± 5.1) to moderate sexual abuse (mean: 7.6 ± 4.6) and moderate physical neglect (mean: 9.2 ± 3.6) according to [Reference Bernstein and Fink39]. Patients reported minimal to low physical abuse (mean: 7.7 ± 4.0). Mean BDI-II scores were 31.0 ± 10.8 indicating severe depressive symptoms [Reference Hiroe, Kojima, Yamamoto, Nojima, Kinoshita and Hashimoto49].

Both loneliness and social network size were significantly associated with the total CTQ score (see Figure 1 and Table 2). Again, the association between loneliness and total CTQ was stronger than the correlation between social network size and total CTQ (Z = 2.0, p < 0.05). Loneliness was significantly associated with all CTQ subscales (except sexual abuse), whereas social network size was only associated with CTQ emotional abuse and neglect subscales.

Mediation analysis revealed comparable results, which were in line with Study 1: Loneliness—but again not social network size—partially mediated the relationship of CM with depressive symptoms (see Figure 2 and Table 3).


The main finding of our studies was the strong association between loneliness and a smaller network size with self-reported CM across two independent samples, that is, a population-based and a clinical sample. Loneliness was particularly associated with emotional neglect and emotional abuse, and regression coefficients between loneliness and CM were significantly larger than coefficients between social network size and CM in both samples. This underlines the importance of clearly defining both constructs and distinguishing the more subjective feeling of loneliness from objective social isolation which can be quantified using the social network size. Regarding their interaction with depressive psychopathology, loneliness but not social network size mediated the relationship between CM and depression in both studies.

Our results of a close relationship between loneliness and CM are in line with a recent meta-analysis that found that individuals with a history of CM feel lonelier than individuals without a history of CM [Reference de Heer, Bi, Finkenauer, Alink and Maes50]. Therefore, CM may constitute a specific vulnerability factor to experience loneliness later in life via different pathways. For instance, Rokach [Reference Rokach51] suggests that growing up in an inadequate or dysfunctional home characterized by emotionally distant or rejecting parents, abuse, and an atmosphere that is generally characterized by upset and unhappiness may lead to developmental deficits as an antecedent of adult loneliness. Individuals with a history of CM may develop difficulties in emotion regulation [Reference Heleniak, Jenness, Stoep, McCauley and McLaughlin22], unhelpful cognitions and schemas [Reference Danese and Widom30], and increased rejection sensitivity (i.e., the readily perception, overreaction, and expectation of rejection [Reference Downey and Feldman21]) that may hinder forming social relationships that offer sufficient social support [Reference Negriff, James and Trickett14Reference McLafferty, O’Neill, Armour, Murphy and Bunting16, Reference Melkman52]. The experience of CM may even bias the perception of adequate and sufficient social support towards unsatisfying relationships that do not fulfill one’s social and emotional needs.

Regarding specific forms of CM, a history of emotional neglect and emotional abuse seems to be particularly associated with perceived loneliness according to our results which is in line with the meta-analytic findings of [Reference de Heer, Bi, Finkenauer, Alink and Maes50]. Emotional neglect is the failure of caretakers or parents to satisfy a child’s emotional needs such as belonging. In contrast, emotional abuse refers to humiliating and demeaning behavior by caretakers. Both emotional neglect and abuse could theoretically induce aversive feelings and support assumptions about being abandoned or even rejected and lead to the expectation that others are emotionally not available [Reference Cicchetti, Toth, Lamb and Lerner17]. The experience of emotional maltreatment and the frequent frustration of emotional needs during childhood may be internalized as deleterious object relations [Reference Dagan and Yager53] that reduce the quality of later relationships and the ability to feel close to others.

Our findings also underline the importance to investigate differences between apparently related phenomena as loneliness and social network size. In general, associations for loneliness with CM were more pronounced than for social network size and CM. Both loneliness and social network size clearly differ in the extent of subjective content with loneliness representing a rather emotional experience that is linked to psychopathology [Reference Nenov-Matt, Barton, Dewald-Kaufmann, Goerigk, Rek and Zentz19], and social network size a more objective measure, though both are usually assessed with self-report scales. Thus, asking for feelings of loneliness may particularly assess the emotional burden of social isolation and reduced quality of interpersonal relationships, and better reflect the level of interpersonal stress [Reference Nenov-Matt, Barton, Dewald-Kaufmann, Goerigk, Rek and Zentz19]. One could speculate that previous CM as retrospectively assessed by the CTQ has led to negative assumptions about interactions and expectations including potential rejection during development making the individual prone to experience burdensome loneliness, whereas the phenomenon of a reduced social network size is not as directly related to CM.

In addition, only loneliness but not social network size mediated the relationship between CM and depressive symptoms. This result is in line with the findings of Wielaard et al. [Reference Wielaard, Hoyer, Rhebergen, Stek and Comijs28] who found that both, loneliness, and social network size, mediated between CM and late-life depression in a sample of older adults when analyzed in separate mediation models. However, when including both as mediators only loneliness stayed significant [Reference Wielaard, Hoyer, Rhebergen, Stek and Comijs28]. Also in this respect, loneliness may be closer to the spectrum of interpersonal stressors and may be one core factor for the development of depressive symptoms. Indeed, Fried et al. [Reference Fried, Bockting, Arjadi, Borsboom, Amshoff and Cramer54] showed in a network model that partner loss mainly affected loneliness, which in turn activated other depressive symptoms. Associations between a variety of psychopathological symptoms, especially depression, and CM are well known [Reference Danese and Widom30, Reference Newbury, Arseneault, Moffitt, Caspi, Danese and Baldwin55], yet the exact mechanisms are unclear in how CM unfolds its negative consequences [Reference McLaughlin, Colich, Rodman and Weissman32]. An insecure attachment style may represent one possible pathway as it has been found that the effect of emotional abuse on depression is partially mediated by an anxious attachment style and in the case of emotional neglect on depression by an avoidant attachment style [Reference Struck, Krug, Feldmann, Yuksel, Stein and Schmitt56].

The results of our two studies further demonstrate similar association patterns in independent samples that differ in terms of their average CM load, levels of loneliness and social network size, underlining the robustness and generalizability of our findings. Interestingly, the associations of loneliness and social network size with CM were stronger in the population-based compared to the clinical sample. Additional clinical and/or neurobiological factors that contribute to or weaken this association need to be identified. Interestingly, a recent study compared different environmental (CM, social support) and neurobiological factors such as neuroimaging findings and polygenic risk scores (PRS) in depressed patients compared to healthy individuals [Reference Winter, Leenings, Ernsting, Sarink, Fisch and Emden57]. Whereas classification accuracy for CM and social support was 71%, it was lower for neuroimaging modalities (ranging between 54 and 55%) and for PRS (58%) underlining the importance of these constructs.

Future research should investigate the mechanistic pathways from CM to loneliness and psychopathology in order to develop tailored treatment options. The interplay of loneliness, a small social network, and psychopathology needs to be further disentangled by taking factors like attachment style, rejection sensitivity, relationship quality, and social support into account. Measuring the effect of specific interventions that unfold over time, for example, addressing unhelpful schemas and expectations, or preventive interventions in children that feel lonely may provide a deeper insight into maintaining factors of loneliness.

Strengths of our study are the replication across independent samples and the parallel assessment of loneliness and social network size addressing the question, which construct shows stronger associations with CM. On the other hand, there are clear limitations: First, a selection bias may have occurred in both, that is, the population-based sample that was recruited via social media during the ongoing COVID-19 pandemic that may have impacted the social network measures, and the clinical sample that consisted of psychiatric inpatients. A cross-diagnostic approach with a larger sample ranging from clinical, to subclinical and nonclinical participants from the general population, may further clarify the association of CM and loneliness. Second, the relatively small clinical sample and partially reduced variance of CTQ subscales hamper further in-depth analysis of our main findings. Third, both studies used self-assessment scales. This may be particularly critical for assessing CM with the CTQ, though this questionnaire is a commonly used instrument for CM. One needs to be aware that the CTQ ask for memories and interpretations related to CM, but does not assess actual records of CM. There is an ongoing debate on the congruence between recorded CM and its retrospective assessment that is driven by the results of recent longitudinal studies. For instance, Baldwin et al. [Reference Baldwin, Reuben, Newbury and Danese58] and Newbury et al. [Reference Newbury, Arseneault, Moffitt, Caspi, Danese and Baldwin55] reported a poor agreement between prospective and retrospective measures of CM. Similarly, Danese and Widom [Reference Danese and Widom30] found that the risk of later psychopathology hardly was associated with objective measures but rather linked to subjective reports even if reports were inconsistent with objective measures. However, the authors also demonstrated that this finding is not caused by a negative autobiographical memory bias due to current psychopathology. Instead, they suggest that it is rather necessary to identify unhelpful cognitions and memories about the self and the environment that may endorse even in the absence of objective maltreatment. These cognitions and memories may be rooted in early adversity and traumatization without representing sound autobiographical information. Nevertheless, they could be an important key to further understanding the role of CM in different perceptual and interpretational processes. Thus, longitudinal studies using documented information and records on CM would be an important step to support our hypothesis.

To conclude, our results suggest a strong association between perceived loneliness and self-reported CM, which appears to be generalizable across populations. CM may increase the vulnerability to experience loneliness later in life which constitutes an aversive inner state closely interacting with the individual psychopathology. Further research investigating causal interactions over the life span, for example, longitudinal studies, is necessary to gain a deeper mechanistic understanding of loneliness, social isolation, and related factors. Focusing on reducing loneliness in psychotherapy may be an interesting approach to buffer the negative consequences of CM on mental health.

Data Availability Statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.


We thank Dr. Marcel Minke from for his support in database set-up and data acquisition.

Author Contributions

M.A.R., S.V.R., R.M., A.J., and F.P. designed research. M.A.R., S.V.R., and F.P. analyzed and interpreted data. M.A.R. wrote first draft of manuscript. All authors revised the work critically and approved the final manuscript and agree to be accountable for the content of the work.

Funding Statement

M.A.R. was supported by the FöFoLePLUS program (grant #003, MCSP) of the Faculty of Medicine of the Ludwig Maximilian University, Munich, Germany. Grants had no role in the study design, collection, analysis, or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication.

Conflicts of Interest

F.P. is a member of the European Scientific Advisory Board of Brainsway Inc., Jerusalem, Israel, and the International Scientific Advisory Board of Sooma, Helsinki, Finland. He has received speaker’s honoraria from Mag&More GmbH and the neuroCare Group. His lab has received support with equipment from neuroConn GmbH, Ilmenau, Germany, and Mag&More GmbH and Brainsway Inc., Jerusalem, Israel. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.


Hawkley, LC, Cacioppo, JT. Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Ann Behav Med. 2010;40(2):218–27. doi:10.1007/s12160-010-9210-8.CrossRefGoogle ScholarPubMed
Heinrich, LM, Gullone, E. The clinical significance of loneliness: a literature review. Clin Psychol Rev. 2006;26(6):695718. doi:10.1016/j.cpr.2006.04.002.CrossRefGoogle ScholarPubMed
Holt-Lunstad, J, Smith, TB, Baker, M, Harris, T, Stephenson, D. Loneliness and social isolation as risk factors for mortality: a meta-analytic review. Perspect Psychol Sci. 2015;10(2):227–37. doi:10.1177/1745691614568352.CrossRefGoogle ScholarPubMed
Qualter, P, Vanhalst, J, Harris, R, Van Roekel, E, Lodder, G, Bangee, M, et al. Loneliness across the life span. Perspect Psychol Sci. 2015;10(2):250–64. doi:10.1177/1745691615568999.CrossRefGoogle ScholarPubMed
Domenech-Abella, J, Lara, E, Rubio-Valera, M, Olaya, B, Moneta, MV, Rico-Uribe, LA, et al. Loneliness and depression in the elderly: the role of social network. Soc Psychiatry Psychiatr Epidemiol. 2017;52(4):381–90. doi:10.1007/s00127-017-1339-3.CrossRefGoogle ScholarPubMed
Erzen, E, Cikrikci, O. The effect of loneliness on depression: a meta-analysis. Int J Soc Psychiatry. 2018;64(5):427–35. doi:10.1177/0020764018776349.CrossRefGoogle ScholarPubMed
van Winkel, M, Wichers, M, Collip, D, Jacobs, N, Derom, C, Thiery, E, et al. Unraveling the role of loneliness in depression: the relationship between daily life experience and behavior. Psychiatry. 2017;80(2):104–17. doi:10.1080/00332747.2016.1256143.CrossRefGoogle ScholarPubMed
Quadt, L, Esposito, G, Critchley, HD, Garfinkel, SN. Brain-body interactions underlying the association of loneliness with mental and physical health. Neurosci Biobehav Rev. 2020;116:283300. doi:10.1016/j.neubiorev.2020.06.015.CrossRefGoogle ScholarPubMed
Peplau, LA, Perlman, D. Loneliness: a sourcebook of current theory, research and therapy. New York: John Wiley & Sons; 1982.Google Scholar
Cornwell, EY, Waite, LJ. Measuring social isolation among older adults using multiple indicators from the NSHAP study. J Gerontol B Psychol Sci Soc Sci. 2009;64(Suppl 1):i38–46. doi:10.1093/geronb/gbp037.CrossRefGoogle ScholarPubMed
Coyle, CE, Dugan, E. Social isolation, loneliness and health among older adults. J Aging Health. 2012;24(8):1346–63. doi:10.1177/0898264312460275.CrossRefGoogle ScholarPubMed
Jacobs, BP. Social care: loneliness. When age brings a crisis, the nurse can restore hope. Nurs Mirror. 1978;147(15):25–7.Google Scholar
Cacioppo, JT, Hawkley, LC. Perceived social isolation and cognition. Trends Cogn Sci. 2009;13(10):447–54. doi:10.1016/j.tics.2009.06.005.CrossRefGoogle ScholarPubMed
Negriff, S, James, A, Trickett, PK. Characteristics of the social support networks of maltreated youth: exploring the effects of maltreatment experience and foster placement. Soc Dev. 2015;24(3):483500. doi:10.1111/sode.12102.CrossRefGoogle ScholarPubMed
Sperry, DM, Widom, CS. Child abuse and neglect, social support, and psychopathology in adulthood: a prospective investigation. Child Abuse Negl. 2013;37(6):415–25. doi:10.1016/j.chiabu.2013.02.006.CrossRefGoogle ScholarPubMed
McLafferty, M, O’Neill, S, Armour, C, Murphy, S, Bunting, B. The mediating role of various types of social networks on psychopathology following adverse childhood experiences. J Affect Disord. 2018;238:547–53. doi:10.1016/j.jad.2018.06.020.CrossRefGoogle ScholarPubMed
Cicchetti, D, Toth, SL. Child maltreatment. In: Lamb, ME, Lerner, RM, editors. Handbook of child psychology and developmental science: socioemotional processes, Hoboken, NJ: John Wiley & Sons; 2015, p. 513–63.Google Scholar
Muller, LE, Bertsch, K, Bulau, K, Herpertz, SC, Buchheim, A. Emotional neglect in childhood shapes social dysfunctioning in adults by influencing the oxytocin and the attachment system: results from a population-based study. Int J Psychophysiol. 2019;136:7380. doi:10.1016/j.ijpsycho.2018.05.011.CrossRefGoogle ScholarPubMed
Nenov-Matt, T, Barton, BB, Dewald-Kaufmann, J, Goerigk, S, Rek, S, Zentz, K, et al. Loneliness, social isolation and their difference: a cross-diagnostic study in persistent depressive disorder and borderline personality disorder. Front Psych. 2020;11:608476 doi:10.3389/fpsyt.2020.608476.CrossRefGoogle ScholarPubMed
Romero-Canyas, R, Downey, G, Berenson, K, Ayduk, O, Kang, NJ. Rejection sensitivity and the rejection-hostility link in romantic relationships. J Pers. 2010;78(1):119–48. doi:10.1111/j.1467-6494.2009.00611.x.CrossRefGoogle ScholarPubMed
Downey, G, Feldman, SI. Implications of rejection sensitivity for intimate relationships. J Pers Soc Psychol. 1996;70(6):1327–43. doi:10.1037/0022-3514.70.6.1327.CrossRefGoogle ScholarPubMed
Heleniak, C, Jenness, JL, Stoep, AV, McCauley, E, McLaughlin, KA. Childhood maltreatment exposure and disruptions in emotion regulation: a transdiagnostic pathway to adolescent internalizing and externalizing psychopathology. Cognit Ther Res. 2016;40(3):394415. doi:10.1007/s10608-015-9735-z.CrossRefGoogle ScholarPubMed
Merz, EM, Jak, S. The long reach of childhood. Childhood experiences influence close relationships and loneliness across life. Adv Life Course Res. 2013;18(3):212–22. doi:10.1016/j.alcr.2013.05.002.CrossRefGoogle Scholar
Palgi, Y, Shrira, A, Ben-Ezra, M, Shiovitz-Ezra, S, Ayalon, L. Self- and other-oriented potential lifetime traumatic events as predictors of loneliness in the second half of life. Aging Ment Health. 2012;16(4):423–30. doi:10.1080/13607863.2011.638903.CrossRefGoogle ScholarPubMed
Rokach, A. Determinants of loneliness of young adult drug users. J Psychol. 2002;136(6):613–30. doi:10.1080/00223980209604823.CrossRefGoogle ScholarPubMed
Rokach, A. Loneliness and intimate partner violence: antecedents of alienation of abused women. Soc Work Health Care. 2007;45(1):1931. doi:10.1300/J010v45n01_02.CrossRefGoogle ScholarPubMed
Steenkamp, L, Weijers, J, Gerrmann, J, Eurelings-Bontekoe, E, Selten, JP. The relationship between childhood abuse and severity of psychosis is mediated by loneliness: an experience sampling study. Schizophr Res. 2022;241:306311. doi:10.1016/j.schres.2019.03.021.CrossRefGoogle Scholar
Wielaard, I, Hoyer, M, Rhebergen, D, Stek, ML, Comijs, HC. Childhood abuse and late-life depression: mediating effects of psychosocial factors for early- and late-onset depression. Int J Geriatr Psychiatry. 2018;33(3):537–45. doi:10.1002/gps.4828.CrossRefGoogle ScholarPubMed
Lin, WH, Chiao, C. Adverse adolescence experiences, feeling lonely across life stages and loneliness in adulthood. Int J Clin Health Psychol. 2020;20(3):243–52. doi:10.1016/j.ijchp.2020.07.006.CrossRefGoogle ScholarPubMed
Danese, A, Widom, CS. Objective and subjective experiences of child maltreatment and their relationships with psychopathology. Nat Hum Behav. 2020;4(8):811–8. doi:10.1038/s41562-020-0880-3.CrossRefGoogle ScholarPubMed
Li, M, D’Arcy, C, Meng, X. Maltreatment in childhood substantially increases the risk of adult depression and anxiety in prospective cohort studies: systematic review, meta-analysis, and proportional attributable fractions. Psychol Med. 2016;46(4):717–30. doi:10.1017/S0033291715002743.CrossRefGoogle ScholarPubMed
McLaughlin, KA, Colich, NL, Rodman, AM, Weissman, DG. Mechanisms linking childhood trauma exposure and psychopathology: a transdiagnostic model of risk and resilience. BMC Med. 2020;18(1):96. doi:10.1186/s12916-020-01561-6.CrossRefGoogle ScholarPubMed
Rek, SV, Buhner, M, Reinhard, MA, Freeman, D, Keeser, D, Adorjan, K, et al. The COVID-19 pandemic mental health questionnaire (CoPaQ): psychometric evaluation and compliance with countermeasures in psychiatric inpatients and non-clinical individuals. BMC Psychiatry. 2021;21(1):426. doi:10.1186/s12888-021-03425-6.CrossRefGoogle ScholarPubMed
Barton, BB, Goerigk, S, Wustenberg, T, Dewald-Kaufmann, J, Reinhard, MA, Musil, R, et al. Altered immediate behavioral response to partial social exclusion: a cross-diagnostic study in patients with borderline personality disorder and persistent depressive disorder. J Psychiatr Res. 2021;144:177–83. doi:10.1016/j.jpsychires.2021.10.005.CrossRefGoogle ScholarPubMed
Reinhard, MA, Padberg, F, Dewald-Kaufmann, J, Wustenberg, T, Goerigk, S, Barton, BB, et al. Sequential social exclusion in a novel cyberball paradigm leads to reduced behavioral repair and plasma oxytocin in borderline personality disorder. J Pers Disord. 2022;36:99115. doi:10.1521/pedi_2021_35_532.CrossRefGoogle Scholar
Russell, D, Peplau, LA, Cutrona, CE. The revised UCLA loneliness scale: concurrent and discriminant validity evidence. J Pers Soc Psychol. 1980;39(3):472–80. doi:10.1037//0022-3514.39.3.472.CrossRefGoogle ScholarPubMed
Döring, N, Bortz, J. Psychometrische Einsamkeitsforschung: Deutsche Neukonstruktion der UCLA Loneliness Scale. Diagnostica. 1993;39:224239.Google Scholar
Cohen, S, Doyle, WJ, Skoner, DP, Rabin, BS, Gwaltney, JM. Social ties and susceptibility to the common cold. JAMA. 1997;277(24):1940–4.CrossRefGoogle ScholarPubMed
Bernstein, DP, Fink, L. Childhood Trauma Questionnaire: a retrospective self-report: manual. San Antonio, TX: The Psychological Corporation; 1998.Google Scholar
Wingenfeld, K, Spitzer, C, Mensebach, C, Grabe, HJ, Hill, A, Gast, U, et al. The German version of the childhood trauma questionnaire (CTQ): preliminary psychometric properties. Psychother Psychosom Med Psychol. 2010;60(11):442–50. doi:10.1055/s-0030-1247564.CrossRefGoogle ScholarPubMed
Klinitzke, G, Romppel, M, Hauser, W, Brahler, E, Glaesmer, H. The German version of the childhood trauma questionnaire (CTQ): psychometric characteristics in a representative sample of the general population. Psychother Psychosom Med Psychol. 2012;62(2):4751. doi:10.1055/s-0031-1295495.Google Scholar
Lovibond, PF, Lovibond, SH. The structure of negative emotional states: comparison of the depression anxiety stress scales (DASS) with the Beck depression and anxiety inventories. Behav Res Ther. 1995;33(3):335–43. doi:10.1016/0005-7967(94)00075-u.CrossRefGoogle ScholarPubMed
Nilges, P, Essau, C. Depression, anxiety and stress scales: DASS--A screening procedure not only for pain patients. Schmerz. 2015;29(6):649–57. doi:10.1007/s00482-015-0019-z.CrossRefGoogle Scholar
Beck, AT, Steer, RA, Ball, R, Ranieri, W. Comparison of Beck depression inventories -IA and -II in psychiatric outpatients. J Pers Assess. 1996;67(3):588–97. doi:10.1207/s15327752jpa6703_13.CrossRefGoogle ScholarPubMed
Hautzinger, M, Keller, F, Kühner, C. BDI-II. Beck-depressions-inventar revision. Frankfurt, Germany: Harcourt Test Services; 2006.Google Scholar
Kuhner, C, Burger, C, Keller, F, Hautzinger, M. Reliability and validity of the revised Beck depression inventory (BDI-II). Results from German samples]. Nervenarzt. 2007;78(6):651–6. doi:10.1007/s00115-006-2098-7.CrossRefGoogle Scholar
R Core Team. A language and environment for statistical computing. Vienna, Austria; R Foundation for Statistical Computing; 2013.Google Scholar
Benjamini, Y, Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Methodol. 1995;57(1):289300.Google Scholar
Hiroe, T, Kojima, M, Yamamoto, I, Nojima, S, Kinoshita, Y, Hashimoto, N, et al. Gradations of clinical severity and sensitivity to change assessed with the Beck depression inventory-II in Japanese patients with depression. Psychiatry Res. 2005;135(3):229–35. doi:10.1016/j.psychres.2004.03.014.CrossRefGoogle ScholarPubMed
de Heer, C, Bi, S, Finkenauer, C, Alink, L, Maes, M. The association between child maltreatment and loneliness across the lifespan: a systematic review and multilevel meta-analysis. Child Maltreat. 2022:10775595221103420. doi:10.1177/10775595221103420.Google ScholarPubMed
Rokach, A. The psychological journey to and from loneliness: development, causes, and effects of social and emotional isolation. New York, NY: Academic Press; 2019.Google Scholar
Melkman, EP. Childhood adversity, social support networks and well-being among youth aging out of care: an exploratory study of mediation. Child Abuse Negl. 2017;72:8597. doi:10.1016/j.chiabu.2017.07.020.CrossRefGoogle ScholarPubMed
Dagan, Y, Yager, J. Addressing loneliness in complex PTSD. J Nerv Ment Dis. 2019;207(6):433–9. doi:10.1097/NMD.0000000000000992.CrossRefGoogle ScholarPubMed
Fried, EI, Bockting, C, Arjadi, R, Borsboom, D, Amshoff, M, Cramer, AO, et al. From loss to loneliness: the relationship between bereavement and depressive symptoms. J Abnorm Psychol. 2015;124(2):256–65. doi:10.1037/abn0000028.CrossRefGoogle ScholarPubMed
Newbury, JB, Arseneault, L, Moffitt, TE, Caspi, A, Danese, A, Baldwin, JR, et al. Measuring childhood maltreatment to predict early-adult psychopathology: comparison of prospective informant-reports and retrospective self-reports. J Psychiatr Res. 2018;96:5764. doi:10.1016/j.jpsychires.2017.09.020.CrossRefGoogle ScholarPubMed
Struck, N, Krug, A, Feldmann, M, Yuksel, D, Stein, F, Schmitt, S, et al. Attachment and social support mediate the association between childhood maltreatment and depressive symptoms. J Affect Disord. 2020;273:310–7. doi:10.1016/j.jad.2020.04.041.CrossRefGoogle ScholarPubMed
Winter, NR, Leenings, R, Ernsting, J, Sarink, K, Fisch, L, Emden, D, et al. More alike than different: quantifying deviations of brain structure and function in major depressive disorder across neuroimaging modalities; 2021. Preprint, arXiv:2112.10730.Google Scholar
Baldwin, JR, Reuben, A, Newbury, JB, Danese, A. Agreement between prospective and retrospective measures of childhood maltreatment: a systematic review and meta-analysis. JAMA Psychiat. 2019;76(6):584–93. doi:10.1001/jamapsychiatry.2019.0097.CrossRefGoogle ScholarPubMed
Figure 0

Table 1. Baseline characteristics of the population-based sample (Study 1) stratified by follow-up participation.

Figure 1

Figure 1. Association of loneliness and smaller social network size with childhood trauma questionnaire (CTQ) in a population-based (non-clinical) and a clinical sample.

Figure 2

Table 2. Regression analyses for loneliness and social network size as dependent variables and childhood trauma questionnaire (CTQ) total score and subscales as predictors in the population-based (Study 1) and clinical sample (Study 2).

Figure 3

Figure 2. Mediation model of childhood maltreatment (CM) as predictor of depression mediated by loneliness and social network size in Study 1 (A) and Study 2 (B).

Figure 4

Table 3. Results of multiple mediation analyses with childhood maltreatment as predictor of depression and loneliness and social network size as mediators.

Submit a response


No Comments have been published for this article.