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Association of depressive symptoms with overactive bladder

Published online by Cambridge University Press:  16 April 2020

D.E. Irwin ,
I. Milsom  and
Z. Kopp
D.E. Irwin
Affiliation:
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
I. Milsom
Affiliation:
Department of Obstetrics & Gynecology, Sahlgrenska Academy At Goteborg University, Goteborg, Sweden
Z. Kopp
Affiliation:
Worldwide Outcomes Research, Pfizer, Inc., New York, NY, USA

Abstract

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Background and aims:

We evaluated depressive symptoms in individuals who reported overactive bladder (OAB) symptoms compared with those without OAB symptoms.

Methods:

A cross-sectional population-based survey was conducted in 5 countries. Computer-assisted telephone interviews were conducted with a geographically stratified random sample of the population (N=19,165). Cases had OAB symptoms (n=1434); controls (n=1434) were randomly selected from participants without OAB within country, age, and gender categories. The Center for Epidemiologic Studies–Depression (CES-D) scale measured depressive symptoms (score range, 0–60). A CES-D score >=21 indicated major depressive symptoms. Participants reported whether they had ever been diagnosed with depression, hypertension, or diabetes. Prevalence odds ratios (PORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression models.

Results:

OAB cases reported significantly more depressive symptoms vs controls (Table 1). OAB cases were significantly more likely to have CES-D scores >=21 vs controls, after controlling for age, gender, country, and comorbidities (Table 2).

Conclusions:

Significantly increased depressive symptoms were reported among individuals with OAB compared with individuals without OAB.

Table 1

CES-D and Self-Reported Depression Diagnosis in Controls and OAB Cases by Gender

 CES-D, MeanCES-D ≥21, %Depression Diagnosis, %
Men
 Controls (n=502)5.183.24.0
 OAB cases (n=502)8.34∗8.9∗12.2∗
Women
 Controls (n=932)6.304.68.6
 OAB cases (n=932)9.87∗13.017.2∗

∗P≤0.05 for OAB vs controls within gender.

Table 2

Conditional Logistic Regression Model∗ to Predict CES-D Score≥21

 POR95% Cl
OAB cases vs controls1.61.1–2.2
Incontinent vs continent1.91.3–2.6
Diabetes vs no diabetes1.61.0–2.5
Hypertension vs no hypertension1.10.8–1.5
Depression history vs no depression history5.84.3–7.8

∗Model controls for country, gender, and age (5-y age bands).

Type
Poster Session 2: Depressive Disorders
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S232
Copyright
Copyright © European Psychiatric Association 2007
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