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Antagonism by modafinil of the psychomotor and cognitive impairment induced by sleep-deprivation in 12 healthy volunteers

Published online by Cambridge University Press:  16 April 2020

G Bensimon ,
D Benoit ,
L Lacomblez ,
E Weiller ,
D Warot ,
JS Weil  and
AJ Puech
G Bensimon
Affiliation:
Service de Pharmacologie Clinique, Division Ambroise-Paré, Hôpital de la Salpêtrière, 47 Bd de l’Hôpital, 75651, Paris Cedex 13
D Benoit
Affiliation:
Laboratoire d’Etude du Sommeil, CNRS URA 1159, Hôpital de la Salpêtrière, 47 Bd de l’Hôpital, 75651, Paris Cedex 13
L Lacomblez
Affiliation:
Service de Pharmacologie Clinique, Division Ambroise-Paré, Hôpital de la Salpêtrière, 47 Bd de l’Hôpital, 75651, Paris Cedex 13
E Weiller
Affiliation:
Service de Pharmacologie Clinique, Division Ambroise-Paré, Hôpital de la Salpêtrière, 47 Bd de l’Hôpital, 75651, Paris Cedex 13
D Warot
Affiliation:
Service de Pharmacologie Clinique, Division Ambroise-Paré, Hôpital de la Salpêtrière, 47 Bd de l’Hôpital, 75651, Paris Cedex 13
JS Weil
Affiliation:
Centre de Recherche du Laboratoire L Lafon, 19 Av du Pr Cadiot, Maison-Alfort, France
AJ Puech
Affiliation:
Service de Pharmacologie Clinique, Division Ambroise-Paré, Hôpital de la Salpêtrière, 47 Bd de l’Hôpital, 75651, Paris Cedex 13
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Summary

Modafinil is a new psychotropic compound with central α1, adrenergic-stimulant activity in animals. In the present study, its pharmacological activity in man was evaluated in the sleep-deprivation induced psychomotor and cognitive impairment paradigm. This was a double-blind placebo-controlled study involving 12 healthy volunteers. Standard psychomotor and memory tasks were used, including critical flicker fusion frequency determination (CFF), choice reaction time and short- and long-term memory evaluation. Results revealed a clear antagonism by modafinil of the psychomotor and cognitive impairment induced by sleep-deprivation in most tasks 6 h after drug administration, and marginal effects 18 h after. These results therefore support a psychostimulant activity of modafinil in man.

Keywords

sleep-deprivationmodafinilpsychostimulantpsychomotor and cognitive performanceshealthy volunteers
Type
Original article
Information
European Psychiatry , Volume 6 , Issue 2 , 1991 , pp. 93 - 97
Copyright
Copyright © Elsevier, Paris 1991

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